A0A6B8VV65 · A0A6B8VV65_9CORY

Function

function

Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.
    EC:5.6.1.7 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

153750100150200250300350400450500
TypeIDPosition(s)Description
Binding site29-32ATP (UniProtKB | ChEBI)
Binding site86-90ATP (UniProtKB | ChEBI)
Binding site413ATP (UniProtKB | ChEBI)
Binding site478-480ATP (UniProtKB | ChEBI)
Binding site494ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcapsule
Cellular Componentcell surface
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP-dependent protein folding chaperone
Molecular Functionisomerase activity
Molecular Functionunfolded protein binding
Biological Processprotein refolding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chaperonin GroEL
  • EC number
  • Alternative names
    • 60 kDa chaperonin
    • Chaperonin-60
      (Cpn60
      )

Gene names

    • Name
      groL2
    • Synonyms
      groEL
      , groL
    • ORF names
      CKALI_09800

Organism names

  • Taxonomic identifier
  • Strain
    • 1959
  • Taxonomic lineage
    Bacteria > Bacillati > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium

Accessions

  • Primary accession
    A0A6B8VV65

Proteomes

Subcellular Location

Cell surface
Cytoplasm
Secreted, capsule
Secreted, cell wall

Keywords

Interaction

Subunit

Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.

Family & Domains

Sequence similarities

Belongs to the chaperonin (HSP60) family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    537
  • Mass (Da)
    56,824
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    0F970B8D6CB3113CE73E4FCB76F5B178
MPKLIAFDEDARKGIQAGVDALADAVKVTLGPRGRNVVLDKPFGGPTVTNDGVTIAREIDLDEPFQNLGAQLVKSVAVKTNDIAGDGTTTATLLAQAMIQEGLRNVAAGANPVELNRGIAAGTEKVLELLQARATEISSSAEIANVATVSSRDQEIGDMVAGAMDKVGKDGVVTVEESQSLETVLDVTEGVSFEKGFLSPYFITDIDAQQAILDNALVLLVRNKISSLPDFVPVLEKIVESGKQVLIIAEDIEGEPLQMLVVNSIRKTLKVVAVKSPYFGDRRKAFMDDLAVVTAATVVDPEVGINLNEADLSMFGAARRITVTKDETIIVDGAGTAEAVEARREQIRREIETTDSTWDKEKAEERLAKLSGGIAVIKVGAATETEVNERKLRVEDAINAARAAAQEGIIAGGGSALVQIAQELKTYAEEFEGDAKIGILALSRALVKPAFWIATNAGVDGSVVVAKTAELPNGEGFNAATLEYGNLLEMGIIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEQAEAGHHHHH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP046452
EMBL· GenBank· DDBJ
QGU02815.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help