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A0A6B3Q6J7 · A0A6B3Q6J7_ENTFC

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-14NAD+ (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site13NADPH (UniProtKB | ChEBI)
Binding site107NADPH (UniProtKB | ChEBI)
Binding site107sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site107substrate
Binding site138sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site140sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site142NAD+ (UniProtKB | ChEBI)
Binding site142NADPH (UniProtKB | ChEBI)
Active site193Proton acceptor
Binding site193sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site246sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site256sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site257NAD+ (UniProtKB | ChEBI)
Binding site257NADPH (UniProtKB | ChEBI)
Binding site257sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site257-258substrate
Binding site258sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site281NADPH (UniProtKB | ChEBI)
Binding site283NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      G3385_08590

Organism names

Accessions

  • Primary accession
    A0A6B3Q6J7

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-162Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain182-322Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    36,640
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    D724E1C8C2CFA756193E35E3A2F2C9F8
MKQKIAVLGPGSWGTALAQTLAENGHDVRIWGNVPEQIDEINKYHTNQHFLPDLTIPESIIGYKELAEAVDNADAILFVVPTKAIRSVAQELIGKMNTKPVIIHASKGLEQDTHKRISEVLAEEIPEEKRQAIVVLSGPSHAEEVAVHDITTITAASIDQKAAAYVQELFMNDYFRIYTNNDVIGVETGAALKNIIAIGAGAIHGLGFGDDAKAAIMTRGLAEISRLGVAMGANPLTFIGLSGVGDLIVTCTSVHSRNWRAGNLLGQGHKLEEVLENMGMVVEGVATTKAAVELAQQLGVEMPITQTIYNVLYNGEDIKKAAKEIMLRDGKMENEFSLR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAHCB010000081
EMBL· GenBank· DDBJ
NEU45874.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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