Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A6B2LJB3 · A0A6B2LJB3_9EUKA

  • Protein
    Inosine triphosphate pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site31Mg2+ (UniProtKB | ChEBI)
Binding site43ITP (UniProtKB | ChEBI)
Binding site59Mg2+ (UniProtKB | ChEBI)
Binding site59-60ITP (UniProtKB | ChEBI)
Binding site135-138ITP (UniProtKB | ChEBI)
Binding site159ITP (UniProtKB | ChEBI)
Binding site164-165ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Amoebozoa > Tubulinea > Elardia > Arcellinida > Sphaerothecina > Arcellidae > Arcella

Accessions

  • Primary accession
    A0A6B2LJB3

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    189
  • Mass (Da)
    20,957
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    ABEDEEA3D108EB134B8AE02A58AC0C19
MGKLREVSAILNDNTEHLPLPIINKVVDLPELQGDAKSVAIEKAKVAVASIQGPCIIEDTCLFFNAWNGLPGPYIKWFMSSCGNEGLNKMLTSYDDKSASATAIFSFCAGVGQPVHLFEGEVKGKIVPSRGSEGFGWDPIFEPEESNGKTFAEMTKDEKNLISHRRRALQKLRTFLLENKDLWTEQPNK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GIBP01008116
EMBL· GenBank· DDBJ
NDV37085.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help