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A0A6B2L6S7 · A0A6B2L6S7_9EUKA

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Amoebozoa > Tubulinea > Elardia > Arcellinida > Sphaerothecina > Arcellidae > Arcella

Accessions

  • Primary accession
    A0A6B2L6S7

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane40-63Helical
Transmembrane69-92Helical
Transmembrane104-124Helical
Transmembrane130-154Helical
Transmembrane186-211Helical
Transmembrane223-242Helical
Transmembrane249-268Helical
Transmembrane274-291Helical
Transmembrane303-322Helical
Transmembrane334-359Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-363Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    371
  • Mass (Da)
    41,234
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    E192D26D501195FCFEB3F721D74F2A3D
MMNDTGLGGADYVGYLYTFYFMLVPFYCIYSGLVIDSGGFALALSSGLLLTLFGTLTTTMAALHSSYPLMLLGRVMSGGCEAVESTLLAYIAIVCRGSLKWEGFAFALSNAMLNLGNVILFFLVPPLLQYGYLYSLGSTVILSVFAILATFAILGMDRRLDLSKERDPEVKESIQLSAIWQQSTKFWLITYLSASNLGIYFNILSFCVLYEYNAGYSTETSGYIPALCSMISLLSPLAMLIIDRYRIHNIVLFSGAIVNVACFFFLSLELPFPFIFFISMGVVYTTSDPIYLELISNEVHQNFLGTAFSLQTIIHAVLHIMYPAIGGWISVRFGWFGFFLFFFGCSTLNLVVLVVYFLLAKRIIGTKYAVI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GIBP01003733
EMBL· GenBank· DDBJ
NDV32702.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

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