A0A6B2EML6 · A0A6B2EML6_KLEPN
- ProteinGlyoxylate/hydroxypyruvate reductase A
- GeneghrA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
Catalytic activity
- (R)-glycerate + NAD+ = 3-hydroxypyruvate + H+ + NADH
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 227 | |||||
Sequence: R | ||||||
Active site | 275 | Proton donor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | glyoxylate reductase (NADPH) activity | |
Molecular Function | hydroxypyruvate reductase [NAD(P)H] activity | |
Molecular Function | NAD binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlyoxylate/hydroxypyruvate reductase A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A6B2EML6
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 105-277 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding | ||||
Sequence: SQVLHWFRRFDDYQALKLASRWQPLPEYRADEFTVGIMGAGVLGAKVAESLQPWGFPLRVWSRSRKSWPQVQSFAGQAELGEFLQGTRVLINLLPNTAETAGIINQTLLAQLPDESYVLNLARGVHVVEEDLLAALNSGKLKGAMLDVFSSEPLPQESPLWAHPRVAMTPHVA |
Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)35,058
- Last updated2020-06-17 v1
- ChecksumDF040863FC6EE538