A0A6A9Q9H7 · A0A6A9Q9H7_ACIIN

  • Protein
    Homocitrate synthase
  • Gene
    lysS
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site112-oxoglutarate (UniProtKB | ChEBI)
Binding site12Mg2+ (UniProtKB | ChEBI)
Binding site752-oxoglutarate (UniProtKB | ChEBI)
Binding site1352-oxoglutarate (UniProtKB | ChEBI)
Binding site1692-oxoglutarate (UniProtKB | ChEBI)
Binding site196Mg2+ (UniProtKB | ChEBI)
Binding site198Mg2+ (UniProtKB | ChEBI)
Active site290Proton acceptor

GO annotations

AspectTerm
Molecular Functionhomocitrate synthase activity
Molecular Functionmetal ion binding
Biological Processlysine biosynthetic process via aminoadipic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homocitrate synthase
  • EC number
  • Short names
    HCS

Gene names

    • Name
      lysS
    • ORF names
      D1867_01015

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 3191
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Acidianus

Accessions

  • Primary accession
    A0A6A9Q9H7

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-257Pyruvate carboxyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    50,420
  • Last updated
    2020-06-17 v1
  • Checksum
    C1896FB9CE605C25
MKVGILDSTLREGEQTPGVVFTTEQRVEIAKALSELGVSMIEAGHPAVSPDIYEGIKRIVKLKKEGEITPEIVGHSRAVKKDIEIAAELEVDRIAIFYGISDIHLKAKTGKTREEALSIIAEAVSYAKEHGAKVRFTAEDATRADLEYLTQVIKTARDAGADRIGIADTVGILYPSKTRELFSYLSKIPGVEYDIHAHNDLGLAVANSLAAVEGGATIIHATVNGLGERVGITPLQVIAAALKYHFNVEVVKLELLPKISSLVEKYSGIPTPPNFPITGDYAFLHKAGIHVQGILNDPRTYEFMPPETFGRNRDYVIDKYTGKHALKDRFERLGVSLSEEELEQVLAKIKSNPNVRFYRDVDLLEIAEEVTGRILKPRPPEKVEALISIKCDSNVYTTAVTRKISVIPGVKEVMEISGDYDILAKIEAKDPTELNNIIESIRSVKGVSSTLTSLVLKKM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WFIY01000004
EMBL· GenBank· DDBJ
MUM63852.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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