A0A6A7SDZ1 · A0A6A7SDZ1_9ZZZZ
- ProteinPenicillin-binding protein 1A
- GenemrcA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids829 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+
[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate RHEA-COMP:9602 + CHEBI:60033 = [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate RHEA-COMP:9603 + CHEBI:58405 + CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | penicillin binding | |
Molecular Function | peptidoglycan glycosyltransferase activity | |
Molecular Function | serine-type D-Ala-D-Ala carboxypeptidase activity | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | proteolysis | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePenicillin-binding protein 1A
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageunclassified sequences > metagenomes > ecological metagenomes
Accessions
- Primary accessionA0A6A7SDZ1
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Single-pass type II membrane protein
Membrane ; Single-pass type II membrane protein
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 59-234 | Glycosyl transferase family 51 | ||||
Sequence: GALIGEFGSQRRIPLRYGEFPPKLINAFIAAEDQRFFEHPGVDYQGIMRAVWHLVRTGEKGPGGSTITMQVARNFFLSPEQTYIRKAREILLALEIDRLLPKEEIMALYLNKIYLGEGAYGAAAAAQIYYGRKPSGLTLAETAMIAGLPKAPSAWNPVANPDRAVERRNYVLRRMH | ||||||
Domain | 321-430 | Penicillin-binding protein OB-like | ||||
Sequence: WRGPAGHWELGESPDAEALRERLDDNYPGVASLTNAVVTGIGEDAVTVVSADRGEAWQLPFDAMAWARPFVNRQVVGKKPGGPGDVLERGDVIRVRDTDEGPRLAQVPEA | ||||||
Domain | 433-709 | Penicillin-binding protein transpeptidase | ||||
Sequence: ALVSLRPEDGAVEALVGGYDFGLSKFNRVLQARRQPGSAFKPLIYSAALANGFTPATLVNDAPVVFHDPSLESTWRPENYSQKFYGPTRLRQALIHSRNLVSIRVLRRVGIGPALAHLARFGLDPEALPHNLSLALGTASLTPMQLARAYTVFSNGGYLVDPYLIDRVENDVGEVVYEPVRLRVCDDGCPSGHAVTAEGAARSAADQGMMQTALADVMPLPERTQSILPAPRVLPADNAWLITSMMQDVIRQGTGRGALVLDRDDLSGKTGTTNDQV | ||||||
Region | 789-829 | Disordered | ||||
Sequence: SMTEYFREGNVPDREPPNAGGGYGSTADGSSSGSGGGKTLF | ||||||
Compositional bias | 812-829 | Polar residues | ||||
Sequence: GSTADGSSSGSGGGKTLF |
Sequence similarities
In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length829
- Mass (Da)90,212
- Last updated2020-06-17 v1
- Checksum54858534EF6F5B36
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 812-829 | Polar residues | ||||
Sequence: GSTADGSSSGSGGGKTLF |