A0A6A7JQQ0 · A0A6A7JQQ0_9BACT

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site116(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site120-122(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site223Plays an important role in substrate specificity
Binding site239(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site348-350(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functiontransaminase activity
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      A2J15_007510
      , GC018_02305
      , GC019_01410
      , GC022_00615

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • HV10
    • QLD_2/QLD
    • VIC_4/VIC
    • VIC_5/VIC
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Campylobacteraceae > Campylobacter

Accessions

  • Primary accession
    A0A6A7JQQ0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue224N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-379Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    45,744
  • Last updated
    2020-06-17 v1
  • Checksum
    DD6D1F867CA00B5A
MSIEIFDKEIFDLTNKELQRQCEGLEMIASENFTLPEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIENLAIQRCKKLFNCQFANVQPNSGSQANQGVYTALINPGDKILGMNLSHGGHLTHGAKVSSSGKIYQSCFYGVELDGRIDYEKVREIAKKEKPKLIVCGASAYARVIDFAKFREIADEVGAYLFADIAHIAGLVVAQEHPDPFPYAHVVSSTTHKTLRGPRGGIIMSNDEELAKKINSAIFPGIQGGPLMHIIAAKAVGFKFNLSAEWKVYARQIKTNAQVLANVLKQRGFKLVSDGTDNHLVLMSFLDREFSGKDADLALGNAGITANKNTVPGEIRSPFVTSGLRLGTPALTARGFKEKEMEIVSNYIADILDDINNVKLQENIKQELKKLASNFIIYERAMF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP031611
EMBL· GenBank· DDBJ
AXP09493.1
EMBL· GenBank· DDBJ
Genomic DNA
WHMJ01000001
EMBL· GenBank· DDBJ
MPV90702.1
EMBL· GenBank· DDBJ
Genomic DNA
WHMG01000002
EMBL· GenBank· DDBJ
MPV95073.1
EMBL· GenBank· DDBJ
Genomic DNA
WHMF01000003
EMBL· GenBank· DDBJ
MPV98025.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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