A0A6A7ASY0 · A0A6A7ASY0_9PLEO
- ProteinHistone acetyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids503 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.
Catalytic activity
- (2E)-butenoyl-CoA + L-lysyl-[protein] = N6-(2E)-butenoyl-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
- 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
- L-lysyl-[protein] + acetyl-CoA = N6-acetyl-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 391 | Proton donor/acceptor | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone H4K16 acetyltransferase activity | |
Molecular Function | transcription coregulator activity | |
Biological Process | DNA repair | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone acetyltransferase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Leptosphaeriaceae > Plenodomus
Accessions
- Primary accessionA0A6A7ASY0
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Component of the NuA4 histone acetyltransferase complex.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 81-125 | Basic and acidic residues | ||||
Sequence: SREVEWPAPEKPEKKKSSAVKHDKAPSKSDQKNLKRSRSKLDREI | ||||||
Region | 81-170 | Disordered | ||||
Sequence: SREVEWPAPEKPEKKKSSAVKHDKAPSKSDQKNLKRSRSKLDREISGTPESTSSNLPGKAQRPSKAGGKENQELTVTSEVTDGTPKPEDE | ||||||
Compositional bias | 126-140 | Polar residues | ||||
Sequence: SGTPESTSSNLPGKA | ||||||
Compositional bias | 148-162 | Polar residues | ||||
Sequence: GKENQELTVTSEVTD | ||||||
Domain | 215-491 | MYST-type HAT | ||||
Sequence: SRVRNLEKIQMGKFEVEPWYFSPYPVDFVDSDVVYICEFCLGYYGEVTQFERHRTKCTLLHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMCTRDEHGCHFVGYFSKEKESAEGYNVACILTLPQYQRKGFGKLLIDFSYLLSKREGRLGSPEKPLSDLGLLGYRAYWQEILVDLLMEPGRQEANIEDLGAATAMTTNDVLHTLQNLNMLRYSKNQHVVVLTDQVIAQRERQKKKEALKGKRSIDPERLIWKP |
Sequence similarities
Belongs to the MYST (SAS/MOZ) family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length503
- Mass (Da)57,781
- Last updated2020-06-17 v1
- ChecksumC603A5D9E6E29A26
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 81-125 | Basic and acidic residues | ||||
Sequence: SREVEWPAPEKPEKKKSSAVKHDKAPSKSDQKNLKRSRSKLDREI | ||||||
Compositional bias | 126-140 | Polar residues | ||||
Sequence: SGTPESTSSNLPGKA | ||||||
Compositional bias | 148-162 | Polar residues | ||||
Sequence: GKENQELTVTSEVTD |
Keywords
- Technical term