A0A6A6MVL8 · A0A6A6MVL8_HEVBR
- ProteinUridine kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids927 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- cytidine + ATP = CMP + ADP + H+
Pathway
Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 694 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 721 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 744 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 792 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 865 | Nucleophile | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | RNA methyltransferase activity | |
Molecular Function | uracil phosphoribosyltransferase activity | |
Molecular Function | uridine kinase activity | |
Biological Process | CTP salvage | |
Biological Process | methylation | |
Biological Process | phosphorylation | |
Biological Process | RNA processing | |
Biological Process | UMP salvage |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridine kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Malpighiales > Euphorbiaceae > Crotonoideae > Micrandreae > Hevea
Accessions
- Primary accessionA0A6A6MVL8
Proteomes
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 23-53 | Disordered | ||||
Sequence: LRLDGLLSSRPSSATNTPAHRTSSASVSASP | ||||||
Compositional bias | 28-53 | Polar residues | ||||
Sequence: LLSSRPSSATNTPAHRTSSASVSASP | ||||||
Domain | 61-247 | Phosphoribulokinase/uridine kinase | ||||
Sequence: VIGVSGGTASGKTTVCDMIIQQLHDHRVVLVNQDSFYRGLTPAELERVHEYNFDHPDAFDTDQLVDCIQKLRSGQPYQVPIYDFKSHRRCSDSFRQVNASDVIILEGILVFHDQRVRNLMNMKIFVDTDADVRLARRIRRDTVERGRDINSVLEQYAKFVKPAFDDFVLPSKKYADVIIPRGGDNHV |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Belongs to the uridine kinase family.
In the C-terminal section; belongs to the UPRTase family.
In the N-terminal section; belongs to the uridine kinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length927
- Mass (Da)103,842
- Last updated2020-06-17 v1
- Checksum867D4DE6584D0BC2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 28-53 | Polar residues | ||||
Sequence: LLSSRPSSATNTPAHRTSSASVSASP |
Keywords
- Technical term