A0A6A6MNI9 · A0A6A6MNI9_HEVBR
- ProteinPhosphomannomutase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.
Catalytic activity
- alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Cofactor
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 13 | Nucleophile | |||
Binding site | 13 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 15 | Proton donor/acceptor | |||
Binding site | 15 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 22 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 129 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 140 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 147 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 185 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 187 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | |||
Binding site | 213 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 225 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 230 | Mg2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | metal ion binding | |
Molecular Function | phosphomannomutase activity | |
Biological Process | GDP-mannose biosynthetic process | |
Biological Process | mannose metabolic process | |
Biological Process | protein N-linked glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomannomutase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Malpighiales > Euphorbiaceae > Crotonoideae > Micrandreae > Hevea
Accessions
- Primary accessionA0A6A6MNI9
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length241
- Mass (Da)27,480
- Last updated2020-06-17 v1
- Checksum8786BC813A07D2FD
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAAGAX010000005 EMBL· GenBank· DDBJ | KAF2315331.1 EMBL· GenBank· DDBJ | Genomic DNA |