A0A6A6MNI9 · A0A6A6MNI9_HEVBR

Function

function

Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site13Nucleophile
Binding site13Mg2+ 1 (UniProtKB | ChEBI)
Active site15Proton donor/acceptor
Binding site15Mg2+ 1 (UniProtKB | ChEBI)
Binding site22alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site129alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site140alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site147alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site185alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site187alpha-D-mannose 1-phosphate (UniProtKB | ChEBI)
Binding site213Mg2+ 1 (UniProtKB | ChEBI)
Binding site225Mg2+ 1 (UniProtKB | ChEBI)
Binding site230Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionphosphomannomutase activity
Biological ProcessGDP-mannose biosynthetic process
Biological Processmannose metabolic process
Biological Processprotein N-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomannomutase
  • EC number

Gene names

    • ORF names
      GH714_038852

Organism names

  • Taxonomic identifier
  • Strain
    • cv. GT1
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Malpighiales > Euphorbiaceae > Crotonoideae > Micrandreae > Hevea

Accessions

  • Primary accession
    A0A6A6MNI9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the eukaryotic PMM family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    27,480
  • Last updated
    2020-06-17 v1
  • Checksum
    8786BC813A07D2FD
MAVRKPGLIALFDVDGTLSAPRKVATPKMLEFMQQLRKVVTVGVVGGSDLSKISEQLGKTVTEDYDYVFSENGLVAYKDGKLIGTQSLKTFLGEEKLKSNFSIIKLIKKIGLNKTFFNNSYRGTFIEFRSGMINVSPIGRNCSQEERDEFEKYDKVHNIRSKMVSVLREKFAHLNLTFSIGGQISFDVFPQGWDKTYCLRYLDEFDEIHFFGDKTYKGGNDHEIYESERTVGHPVQKKQTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAGAX010000005
EMBL· GenBank· DDBJ
KAF2315331.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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