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A0A6A1UNE5 · A0A6A1UNE5_9ROSI

  • Protein
    Cytoplasmic tRNA 2-thiolation protein 1
  • Gene
    NCS6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Pathway

tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.

Features

Showing features for binding site.

135650100150200250300350
TypeIDPosition(s)Description
Binding site67-69ATP (UniProtKB | ChEBI)
Binding site73ATP (UniProtKB | ChEBI)
Binding site99ATP (UniProtKB | ChEBI)
Binding site177ATP (UniProtKB | ChEBI)
Binding site182ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosolic tRNA wobble base thiouridylase complex
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular Functionnucleotidyltransferase activity
Molecular FunctiontRNA binding
Biological Processprotein urmylation
Biological ProcesstRNA wobble position uridine thiolation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytoplasmic tRNA 2-thiolation protein 1
  • EC number
  • Alternative names
    • Cytoplasmic tRNA adenylyltransferase 1

Gene names

    • Name
      NCS6
    • Synonyms
      CTU1
    • ORF names
      CJ030_MR0G000136

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fagales > Myricaceae > Morella

Accessions

  • Primary accession
    A0A6A1UNE5

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain64-247tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Domain291-321Cytoplasmic tRNA 2-thiolation protein 1 C-terminal
Region329-356Disordered

Sequence similarities

Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    40,478
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    85B0C1696DACB7FC5CFA3CD0EEE4B454
MEGADSKPVKVRGRQCCICDKRRAALKRPKTLEQICRECFYEVFEEEIHQVIVQNQLFKPGERIAIGASGGKDSTVLAYVLSELNRRHNYGLDLFLLSVDEGITGYRDDSLETVKRNEIQYRLPLKIVSYKDLYGWTMDEIVKMIGLKNNCTFCGVFRRQALDRGAALLKVDKLATGHNADDIAETVLLNILRGDIARLSRCTSIVTGEDGPIPRCKPFKYTYEKEIVMYAYFKRLDYFSTECIYSPNAYRGFAREFIKDLERMRPRAILDIIQSGEDFRISTSTKMPEQGTCERCGYISSQKWCKACVLLEGLNRGLPKLGIGRSRGLNNDHTKGAKESNGTKSFESKQCGTLDF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RXIC02000027
EMBL· GenBank· DDBJ
KAB1201723.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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