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A0A6A1UM24 · A0A6A1UM24_9ROSI

  • Protein
    Folylpolyglutamate synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a monovalent cation (UniProtKB | Rhea| CHEBI:60242 )

Note: A monovalent cation.

Pathway

Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site110Mg2+ 1 (UniProtKB | ChEBI)
Binding site179Mg2+ 1 (UniProtKB | ChEBI)
Binding site207Mg2+ 1 (UniProtKB | ChEBI)
Binding site329ATP (UniProtKB | ChEBI)
Binding site359ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processone-carbon metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      CJ030_MR0G003680

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fagales > Myricaceae > Morella

Accessions

  • Primary accession
    A0A6A1UM24

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    590
  • Mass (Da)
    65,201
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    ED7A0AD7A17482115F80ECAA1A98CB1F
MSSEVVEKMVTDVVVKECVQDFPLPSSYEAAMEALSSLITRRNRGDKSSVGGKYGKLERMSEYLKILGLKEQIDGLNIIHVAGTKGKGSTCTFSEAILRECGFQTGLFTSPHLIDVRERFRINGLEISEDKFLQYFWDCWNQLKEKVTEHLPMPPLFQFLTVLAFKIFICEKVDVAIIEVGLGGQKDSTNVIEKPIVCGIASLGMDHTETLGNTLGSIASHKAGIFKPQIPAFTVPQLSEAMDVILERAHELKVPLNVAAPLDKTKLGGLKLSLSGDHQFINAGLAVSLCKCWLQRTGNWEKLFQNDIREADLPEAFLRGLSTAQIAGRAQIVCDMYSESSKSLNSSKNSCGDLIFYLDGAHSPESMEFCAKWFSSAVGGIKKSSPSSIKVDNNEEILGNGHIQHKSERMEESDKLLKQILLFNCMDVRDPQTLLPPLVSTCTSSGTRFSKALFVPSMSTYNKVTSGASVIPSDICSRDLSWQFHLQRLWEKVIHGKGLSVHNAEVGTLNDRGARMDKATILPPHEFLYEDASHCSPAENYFACSAVMPSLPLTIKWLRDCVKENPSLKVQVLVTGSLHLVGDVLKLLKR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RXIC02000066
EMBL· GenBank· DDBJ
KAB1201445.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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