A0A679HQZ5 · A0A679HQZ5_9BACT

  • Protein
    Amidophosphoribosyltransferase
  • Gene
    purF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site19Nucleophile
Binding site253[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site301Mg2+ (UniProtKB | ChEBI)
Binding site363Mg2+ (UniProtKB | ChEBI)
Binding site364Mg2+ (UniProtKB | ChEBI)
Binding site400[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site451[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site454[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • ORF names
      W02_39740

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KM1
  • Taxonomic lineage
    Bacteria > Nitrospirota > Nitrospiria > Nitrospirales > Nitrospiraceae > Nitrospira

Accessions

  • Primary accession
    A0A679HQZ5

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-237Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    52,269
  • Last updated
    2020-06-17 v1
  • Checksum
    1631511B9FB8D36F
MQTQKDLPLVTPDKFHDECAVFGIYGHEEAANLTYLGLYALQHRGQEASGIVSGDGEQFCVQKGMGLVADIYNKSALEKLPGHMAIGHNRYSTTGGNDLKNVQPLTVNFAFGNLALAHNGNLINAQVLRHELEAYGAIFQSTSDSEVIIHLIAHSRADTFLARVIDALSQVRGAFSVVLMTDNGLIAARDPYGLRPLCIGKIRSSWIVASETCAFDLLDAEYVREVEPGELVVLSEQGMESHHPFPTVNPAMCVFEYVYFARPDSKIFGANAVYATRKALGRQLAEESWVPADIVIPVPDSGVPAALGYAEGGGIRFETGLIRNHYVGRTFIEPEQSIRHFGVKVKLNAVSEVLEGKRVVVVDDSLVRGTTSRKIVKMIRNAGAKEVHMRISSPPIISPCFYGIDTPTKKELIASSHSTEEIRKYITADSLAYLSLDGMLKAAPGTPTQYCSACFTERYPISFTRAEELQLGLFEPSS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP022671
EMBL· GenBank· DDBJ
BCA56834.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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