A0A679HHJ3 · A0A679HHJ3_9BACT
- ProteinGlucose-6-phosphate 1-dehydrogenase
- Genezwf1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 28-35 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GGSGDLAR | ||||||
Binding site | 62 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 171 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 201 | substrate | ||||
Sequence: H | ||||||
Binding site | 205 | substrate | ||||
Sequence: K | ||||||
Binding site | 239 | substrate | ||||
Sequence: E | ||||||
Binding site | 258 | substrate | ||||
Sequence: D | ||||||
Active site | 263 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 363 | substrate | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
- Short namesG6PD
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Nitrospirota > Nitrospiria > Nitrospirales > Nitrospiraceae > Nitrospira
Accessions
- Primary accessionA0A679HHJ3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-210 | Glucose-6-phosphate dehydrogenase NAD-binding | ||||
Sequence: VIFGGSGDLARRKLIPALYNLLLDGLLPSNYAVLGLGRKTMTDEEYRATLREGVVKFSRQALDEDKWGAFARHVFYVSGENENPATYSTLRSRAEEVERQLGLPGNRIFYLSIPPSSFTAVCEGLATAGMTSHSTSPAPYARIIVEKPVGHDLASAKDINSVTARVFDESQIFRIDHYLGKETVQN | ||||||
Domain | 212-511 | Glucose-6-phosphate dehydrogenase C-terminal | ||||
Sequence: MVVRFANIIFEPIWNHKYIDHVQITVSEAEGVGTRASYYEEAGALRDMVQNHILQLLCLVAMEPPYSLDPDVVRNAKMEVLRCLRPIVGKDVEKYTVRAQYAGGAVNGTAVPGYRRESGVKPNSTTETYVAIKCFVENWRWSGVPFYLRTGKALPHRASEVAVQFKEIPQILFNSNTQHPQPPNVLALRIQPEEGLSLRIVSRVPGTRAYTHPVEMNFEYAEVFGRPSPEAYERLLLDVMTGDASRFMRRDAVEASWAWITKILEGWQQQGSRWLPEYPAGTSGPVEADRLIQEDGRSWR |
Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)57,526
- Last updated2020-06-17 v1
- Checksum87E7353ADB68FB82
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP022671 EMBL· GenBank· DDBJ | BCA53854.1 EMBL· GenBank· DDBJ | Genomic DNA |