A0A679E720 · A0A679E720_9FLAV

  • Protein
    Genome polyprotein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    5/5

Function

function

Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentviral capsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionprotein dimerization activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type peptidase activity
Biological Processfusion of virus membrane with host endosome membrane
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 16GH36
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus

Accessions

  • Primary accession
    A0A679E720

Subcellular Location

Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host nucleus
Secreted
Virion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane122-142Helical
Transmembrane1141-1160Helical
Transmembrane1180-1200Helical
Transmembrane1207-1224Helical
Transmembrane1230-1249Helical
Transmembrane1261-1289Helical
Transmembrane1336-1353Helical
Transmembrane1406-1432Helical
Transmembrane2097-2122Helical
Transmembrane2173-2193Helical
Transmembrane2200-2218Helical
Transmembrane2263-2284Helical
Transmembrane2296-2314Helical
Transmembrane2320-2346Helical
Transmembrane2409-2425Helical
Transmembrane2437-2465Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Forms a heterodimer with serine protease NS3. May form homooligomers.
Forms heterodimers with envelope protein E in the endoplasmic reticulum and Golgi.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-62Disordered
Compositional bias23-41Basic and acidic residues
Domain1455-1634Peptidase S7
Domain1665-1769Helicase ATP-binding
Domain1780-1955Helicase C-terminal
Domain2473-2727MRNA cap 0-1 NS5-type MT
Domain2991-3138RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,363
  • Mass (Da)
    373,300
  • Last updated
    2020-06-17 v1
  • Checksum
    BDDDFC6D20A979C8
MGRDDGKKKKGPGSSRWLLPSERAGLGRKEEKKKKEKRSVRSTPQLVSGGAQHRRGGGMGPRARGLLGRLGIGWGSILQEDIVQALMHLVLVLHSVFIAIDRRLRSLTRRVTALEAKRSAKNAVRITLILTGLMMVLGAVVIDMQVSTAKGTQIFEGKTNRTDHVHLFKLPTDGCWSGTLVMKKCPKVADLAKDLEGVDCGSSWTEFTLRYHRCVPKKRERRAANTNQKLDFLAEVELVTFKAIRENKTIAIIVLLCVAIAKRWPMWVVILLAIGTWTTVKGEFVEPLYTLKAEKMTMLQTIMRPDESYVISTPNGLLEFRTGAAEIYGGQWMRELLADCHANASYSTDVCPGGSQLNMGEINGKERVCSTQPYNRGWGTGCFKWGIGFVATCVELHCEEGYNVSSIARSSIVMNITAKFHSVDDVQQLISDVPVTFRFAKLGNAAVTCRLESERLLLDYYHVTGKYHEGLFVRSQIDEWPGAHATASGRAGLERIVVWGDARANEVLVKNILEPQLIWDNAIATQDGFRDVGFSCQIMLDKLVSGSFKDCPGIKSSVFVQSGFGYDGVVMTSLSKATNESCSVGLTCHGCYLLATKMVFGPGTSTAKAFVGCGNHTGTLVIGGTTIHVECVLNPISQGWRMAKHVVDKYRRFGTAGVGGVWYDFVGKFSLFSLLSSSTILVGLAALVLLDKRIVFLLLLCGYFIYTKADVGCGFDPERKVVSCGSGGFVWKSLSQWPTREHSVELDDQHLITALVSEQLKKTNKVCIICEDVLQCAAARGAVGDITHVDNEIVYVNTSLSFDRTFPRIPKKVHGVKIGDLTMQLALASVGGAVDPSQYGELSSGFLSRTKIAETGEHKVIRVITSASPYEKICEQAFALQYGFVRFTRRVFGSNVVVKPVAKPTDYCPTYLAGSFVKNDIGAYTDGMMWMKSKKVNGTWTLVDLELTQSHQCIWPQAYTFDLTAFNDSSLFMPAQYGAPMSKANHIPGYKTQTEFPWYKADIVLREGVVPGTQVEESPSCDNRGSAVKVDPAIAKKWCCKTCLSADKRVFHFKVDNDYFYPMEIRPAATQPEVTIDADGEDMDEMASMFGTMKAVVPPVEGSYPDFRLSPSVEGVSPLLVGALLHLLTIRTKHRWAQRTCGTWILFLLFGVPSNTYAGWSWIGLSYSLAAVPNGSALLVHFWLAVQLSSSHLFFLGWALRQRVRSSVGYALSVFFAEWLLLKLRQLWESTYLLDHVLFPMYVMLAFNLKSQFVPVDSMVLLNYVVTHPAVATATVTGGALVICSIRVYKNWGCSPNLWRSGLRASKPSLIAGMCLAGLYVLSTCLEFYQMPTTASVVFLGGLLIGIVTRMAPPTHLELVPVAGTGVPLDCEEEPTILPSGLEGTYGPDGVEFTNLTDNSRVSTGLLVYVGCMGVMAMNTYVGVILMCACWWTNAPEWLPLYVAGSSIFRSNEVNDVLITPPEYEQEAQLSNDFGHLPDGTYRVVARSLFMTSHVGAGYAKDGVFNTLWHVTSGGSLTWQGRHVRLHSGDVYRDMASYGGPWNIADSPESSVVVRVVQNDGSVLCARSSTASISVDGKRVQVIGHDYGKGSSGSPVHALDGRVVGLYGYGFFIGWKYHSLITSGEVVAEDTVEEDTVSRRFVDWHPGKGKTRRVLVEEAKSHIAKEKRLLILTPTRVVKDEVVRAIAEACPGVVVGSNLAMYRRNAITVACHATLTQYLMEKGIDSIRFSTIIMDECHFLDPLSIACRGVMDYYNGKGVAVVYMSATPPGCAGNNGSNHPIADVATQFPRELTASWVRGQANGKTIIFVPTQHQANTLASELGGVSLTRESFDVAIGKARRQETQFIVSTDISEMGANLGVQTVIDTRVAVKPVISEGSVMLEKVGITQASAIQRRGRTGRREAGKYVYPIGSELENEATEWACWTEAQMILDQMACGPMREEIENFQPQGTYLLAPESRPRFINFIKKDVPVWLAWHWANAFEHKHSVLFQGQNATSLKIRTEAGDHKYAPRFHDDRFEKNNELDKRSKIMLYLKQRSNFNFDLGGVLYGLFVAFRDTNMERLGTSYRSAIEILHEISNVDDPMVSNVVMGKSLQAWAAVIIGMVTGIVLLVVFVVVCRCVKRLFGGKAAAQQSPPYSSFPTVQAAGFCQFGSMVMAIGPLCAVVAGIPPAFVFVAVLGLFVIMCCSANNVHRAYTTDTVTLVVIGVCVCVMGVVAWEMDLLPNIRRDLGYLLERFASKQEPDIPQASFARPEVPELHITSLPGALVVSFAIAIVGGAIANCLSDSGFLRKLFSNEEQSAAVIGGIQLALISWETLVPVAFAGFFATTFVTKIYGCMVGGIYLVLAHYDRKYAFTVKATKVLIARTSRKDLDDEITGRDGVTRGRPTFYALQICCSLLWTITSPSLKHVVVSVAVIVFAFLTFRRPNNRLLVTFDYSSVLLILMIFAEPGQVFLVGASLLFWFVAHQSRMALRSLVKTDACGLGYRWKEMLNALDKNAFDKYRSRGVNETEKGDFVSRGGLKMDELIRKFQWEPRGAALDLGCGRGGWTQRLVMDTRVNSVMGLTLGGASRENPLPFKTKGHNLAVLKAGVDVYALEPRDCNTIVCDIGESDPRPEVEKTRTLKVLTMLEKWLIHNPGAAFCCKVLSPYHLEVLRKLEMLQHKHNGKLVRLSLSRNSTAEMYYVSGPRANIVGSVFHVLGALIGRFKRNDPVQRDAPPKLEMGTRSDPRAKVKLQDPTIVAGRVKRLREENASTWFVDREHPYQSFNYHGSFVTDDISPGGQTVNPMMRRIMWPWDFLSRVTTFMMTDVSTYAQQKILREKVDTLTLEPDQRTRAINRLIMRHFSAMFKRRGLTPRILTPVEYMSNVKSGAAIGGWSKEMPWNKVQEALADPVFWRMVADERARHLRGDCELCVFNTMGKKEKKPSSFGEARGSRIIWYMWLGSRFLEYEALGFLNEDHWVARKNFPCGVGGVGVNYFGYYLKEIMQKGKWMIADDVAGWDTRITEADLEDELWFLLDQVNDPYHAKLIRVVFKFCYMNMVALFPRNHPQFRSGTVFDVVSRTDQRGSGQVTTYALNTVTNGKNQVGRMLEAEGLLDAPLEVIDGWLSSHLEDVLSGMVVAGDDVVVATNNENFHTSLRYITAASKTRKNLQPTEPSPRYTSWEHVEFCSHHYHPLVLQDGREIIAPCRDQHEIIGRARIQKGGIVDMSAAGCLAKAHAQMWALYYFHRRDLRLGFAAITSAVPVNWIPTGRISWSVHQHAEWMTTQDMLEVWNTVWIVNNPWMATKDLVKAWSEIPYLPKTKDINCGSLIGERDRAAWSKNIVSTVSTTRRIIEQEAGSQKFTEGLRILGRYRAPADDVFW

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias23-41Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC504568
EMBL· GenBank· DDBJ
BBO25549.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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