A0A679E720 · A0A679E720_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3363 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus
Accessions
- Primary accessionA0A679E720
Subcellular Location
UniProt Annotation
GO Annotation
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 122-142 | Helical | ||||
Sequence: NAVRITLILTGLMMVLGAVVI | ||||||
Transmembrane | 1141-1160 | Helical | ||||
Sequence: CGTWILFLLFGVPSNTYAGW | ||||||
Transmembrane | 1180-1200 | Helical | ||||
Sequence: VHFWLAVQLSSSHLFFLGWAL | ||||||
Transmembrane | 1207-1224 | Helical | ||||
Sequence: SVGYALSVFFAEWLLLKL | ||||||
Transmembrane | 1230-1249 | Helical | ||||
Sequence: STYLLDHVLFPMYVMLAFNL | ||||||
Transmembrane | 1261-1289 | Helical | ||||
Sequence: LLNYVVTHPAVATATVTGGALVICSIRVY | ||||||
Transmembrane | 1336-1353 | Helical | ||||
Sequence: SVVFLGGLLIGIVTRMAP | ||||||
Transmembrane | 1406-1432 | Helical | ||||
Sequence: LLVYVGCMGVMAMNTYVGVILMCACWW | ||||||
Transmembrane | 2097-2122 | Helical | ||||
Sequence: AWAAVIIGMVTGIVLLVVFVVVCRCV | ||||||
Transmembrane | 2173-2193 | Helical | ||||
Sequence: FVFVAVLGLFVIMCCSANNVH | ||||||
Transmembrane | 2200-2218 | Helical | ||||
Sequence: TVTLVVIGVCVCVMGVVAW | ||||||
Transmembrane | 2263-2284 | Helical | ||||
Sequence: LPGALVVSFAIAIVGGAIANCL | ||||||
Transmembrane | 2296-2314 | Helical | ||||
Sequence: NEEQSAAVIGGIQLALISW | ||||||
Transmembrane | 2320-2346 | Helical | ||||
Sequence: VAFAGFFATTFVTKIYGCMVGGIYLVL | ||||||
Transmembrane | 2409-2425 | Helical | ||||
Sequence: HVVVSVAVIVFAFLTFR | ||||||
Transmembrane | 2437-2465 | Helical | ||||
Sequence: YSSVLLILMIFAEPGQVFLVGASLLFWFV |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Forms a heterodimer with serine protease NS3. May form homooligomers.
Forms heterodimers with envelope protein E in the endoplasmic reticulum and Golgi.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-62 | Disordered | ||||
Sequence: MGRDDGKKKKGPGSSRWLLPSERAGLGRKEEKKKKEKRSVRSTPQLVSGGAQHRRGGGMGPR | ||||||
Compositional bias | 23-41 | Basic and acidic residues | ||||
Sequence: RAGLGRKEEKKKKEKRSVR | ||||||
Domain | 1455-1634 | Peptidase S7 | ||||
Sequence: NDVLITPPEYEQEAQLSNDFGHLPDGTYRVVARSLFMTSHVGAGYAKDGVFNTLWHVTSGGSLTWQGRHVRLHSGDVYRDMASYGGPWNIADSPESSVVVRVVQNDGSVLCARSSTASISVDGKRVQVIGHDYGKGSSGSPVHALDGRVVGLYGYGFFIGWKYHSLITSGEVVAEDTVEE | ||||||
Domain | 1665-1769 | Helicase ATP-binding | ||||
Sequence: KEKRLLILTPTRVVKDEVVRAIAEACPGVVVGSNLAMYRRNAITVACHATLTQYLMEKGIDSIRFSTIIMDECHFLDPLSIACRGVMDYYNGKGVAVVYMSATPP | ||||||
Domain | 1780-1955 | Helicase C-terminal | ||||
Sequence: PIADVATQFPRELTASWVRGQANGKTIIFVPTQHQANTLASELGGVSLTRESFDVAIGKARRQETQFIVSTDISEMGANLGVQTVIDTRVAVKPVISEGSVMLEKVGITQASAIQRRGRTGRREAGKYVYPIGSELENEATEWACWTEAQMILDQMACGPMREEIENFQPQGTYLL | ||||||
Domain | 2473-2727 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: LRSLVKTDACGLGYRWKEMLNALDKNAFDKYRSRGVNETEKGDFVSRGGLKMDELIRKFQWEPRGAALDLGCGRGGWTQRLVMDTRVNSVMGLTLGGASRENPLPFKTKGHNLAVLKAGVDVYALEPRDCNTIVCDIGESDPRPEVEKTRTLKVLTMLEKWLIHNPGAAFCCKVLSPYHLEVLRKLEMLQHKHNGKLVRLSLSRNSTAEMYYVSGPRANIVGSVFHVLGALIGRFKRNDPVQRDAPPKLEMGTRS | ||||||
Domain | 2991-3138 | RdRp catalytic | ||||
Sequence: KWMIADDVAGWDTRITEADLEDELWFLLDQVNDPYHAKLIRVVFKFCYMNMVALFPRNHPQFRSGTVFDVVSRTDQRGSGQVTTYALNTVTNGKNQVGRMLEAEGLLDAPLEVIDGWLSSHLEDVLSGMVVAGDDVVVATNNENFHTS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,363
- Mass (Da)373,300
- Last updated2020-06-17 v1
- ChecksumBDDDFC6D20A979C8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-41 | Basic and acidic residues | ||||
Sequence: RAGLGRKEEKKKKEKRSVR |