A0A679DT32 · A0A679DT32_9BETC

  • Protein
    Hemagglutinin-esterase
  • Gene
    HE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site40Nucleophile
Active site326Charge relay system
Active site329Charge relay system

GO annotations

AspectTerm
Cellular Componenthost cell plasma membrane
Cellular Componentplasma membrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Molecular Functionhost cell surface receptor binding
Molecular Functionsialate O-acetylesterase activity
Biological Processfusion of virus membrane with host plasma membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hemagglutinin-esterase
  • EC number
  • Short names
    HE protein
  • Alternative names
    • E3 glycoprotein

Gene names

    • Name
      HE

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IWT-12
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Embecovirus > Betacoronavirus 1

Accessions

  • Primary accession
    A0A679DT32

Subcellular Location

Host cell membrane
; Single-pass type I membrane protein
Virion membrane
; Single-pass type I membrane protein
Note: In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.

Features

Showing features for transmembrane, topological domain.

Type
IDPosition(s)Description
Transmembrane392-415Helical
Topological domain414-424Intravirion

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

Type
IDPosition(s)Description
ChainPRO_502574320217-424Hemagglutinin-esterase
Disulfide bond44↔65
Disulfide bond113↔162
Disulfide bond307↔312
Disulfide bond347↔371

Post-translational modification

N-glycosylated in the host RER.

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. Forms a complex with the M protein in the pre-Golgi. Associates then with S-M complex to form a ternary complex S-M-HE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-377Haemagglutinin-esterase glycoprotein core
Domain129-263Haemagglutinin-esterase glycoprotein haemagglutinin

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    47,575
  • Last updated
    2020-06-17 v1
  • Checksum
    EF7752B4DCA23B1F
MFLLPRFVLVSCIIGSLGFDNPPTNVVSHLNGDWFLFGDSRSDCNHVVTTNPRNYSYMDLNPALCGSGKISSKAGNSIFRSFHFTDFYNYTGEGQQIIFYEGVNFTPYHAFKCTTSGSNDIWMQNKGLFYTQVYKNMAVYRSLTFVNVPYVYNGSAQSTALCKSGSLVLNNPAYIALEANFGDYYYKVEADFYLSGCDEYIVPLCIFNGKFLSNTKYYDDSQYYFNKDTGVIYGLNSTETITTGFDFNCHYLVLPSGNYLAISNELLLTVPTKAICLNKRKDFTPVQVVDSRWNNARQSDNMTAVACQPPYCYFRNSTTNYVGVYDINHGDAGFTSILSGLLYDSPCFSQQGVFRYDNVSSVWPLYPYGRCPTAADINTPDVPICVYDPLPIILLGILLGVAVIIIVVLLLYFMVDNGTRLHDA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC494138
EMBL· GenBank· DDBJ
BBM61036.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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