A0A679DSA2 · A0A679DSA2_9ORTO
- ProteinHemagglutinin-esterase-fusion glycoprotein
- GeneHEF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids664 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.
Catalytic activity
- H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | viral envelope | |
Molecular Function | host cell surface receptor binding | |
Molecular Function | sialate O-acetylesterase activity | |
Biological Process | fusion of virus membrane with host endosome membrane | |
Biological Process | fusion of virus membrane with host plasma membrane | |
Biological Process | symbiont entry into host cell | |
Biological Process | virion attachment to host cell |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHemagglutinin-esterase-fusion glycoprotein
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Deltainfluenzavirus > Deltainfluenzavirus influenzae
Accessions
- Primary accessionA0A679DSA2
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Host cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 635-662 | Helical | ||||
Sequence: YYLGSTIALCLLGLVAIAAFVGVIWVCC |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homotrimer of disulfide-linked HEF1-HEF2.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 49-422 | Haemagglutinin-esterase glycoprotein core | ||||
Sequence: MTGFTNVTKGASVINQGDWIGFGDSRTDLNNDQFPASSDVPLVVAKKFRSLSGASLMLSAFGPPGKVDYLYQGCGKEKVFYEGVNWSPEAKIDCFGSNWTQTKKDFYSRIYEAARGSTCMTLVNSLDTKISSTTATAGTTSTCSSSWMKSPLWYDESSVNPRASSQVCGTEQSATFTLPTSFGIYKCNKHVVQLCYFVYENKTAFNTFGCGDYYQNYYDGNGNLIGGMDNRVAAYRGIAGAGVKIECPSKILRPGTYSIRSTPRFLLVPKRSYCFDTDGGYPIQVVQSEWSASRRSDNATEEACLQTEGCIFIKKTTPYVGEADDNHGDTEMRQLLSGLGSNDTVCVSQSGYTKGETPFVKDYLSPPKYGRCQL | ||||||
Domain | 154-310 | Haemagglutinin-esterase glycoprotein haemagglutinin | ||||
Sequence: FYSRIYEAARGSTCMTLVNSLDTKISSTTATAGTTSTCSSSWMKSPLWYDESSVNPRASSQVCGTEQSATFTLPTSFGIYKCNKHVVQLCYFVYENKTAFNTFGCGDYYQNYYDGNGNLIGGMDNRVAAYRGIAGAGVKIECPSKILRPGTYSIRST | ||||||
Domain | 456-628 | Haemagglutinin stalk influenza C | ||||
Sequence: IFGIDDLIFGFLFIGFVAGGVAGGYFWGRSSAGGGGASVSSTQAGFDKIGKDIQQLRNDTNAAIEGFNGRIAHDEQAIKNLAKEIEDARAEALVGELGIIRSLIVANISMNLKESLYELANQITKRGGGIAQEAGPGCWYVDSENCDASCKEYIFNFNGSAPVPTVRTVDTSV |
Sequence similarities
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length664
- Mass (Da)71,761
- Last updated2020-06-17 v1
- Checksum4BFBE9C1445C4FE4