A0A679DSA2 · A0A679DSA2_9ORTO

  • Protein
    Hemagglutinin-esterase-fusion glycoprotein
  • Gene
    HEF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.

Catalytic activity

GO annotations

AspectTerm
Cellular Componenthost cell plasma membrane
Cellular Componentplasma membrane
Cellular Componentviral envelope
Molecular Functionhost cell surface receptor binding
Molecular Functionsialate O-acetylesterase activity
Biological Processfusion of virus membrane with host endosome membrane
Biological Processfusion of virus membrane with host plasma membrane
Biological Processsymbiont entry into host cell
Biological Processvirion attachment to host cell

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hemagglutinin-esterase-fusion glycoprotein
  • EC number

Gene names

    • Name
      HEF

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • D/bovine/Yamagata/1/2019
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Deltainfluenzavirus > Deltainfluenzavirus influenzae

Accessions

  • Primary accession
    A0A679DSA2

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Host cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane635-662Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homotrimer of disulfide-linked HEF1-HEF2.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-422Haemagglutinin-esterase glycoprotein core
Domain154-310Haemagglutinin-esterase glycoprotein haemagglutinin
Domain456-628Haemagglutinin stalk influenza C

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    664
  • Mass (Da)
    71,761
  • Last updated
    2020-06-17 v1
  • Checksum
    4BFBE9C1445C4FE4
MFLLLATITAITACQAERELICIVQRVNESFSLHSGFGGNVYSTKTEPMTGFTNVTKGASVINQGDWIGFGDSRTDLNNDQFPASSDVPLVVAKKFRSLSGASLMLSAFGPPGKVDYLYQGCGKEKVFYEGVNWSPEAKIDCFGSNWTQTKKDFYSRIYEAARGSTCMTLVNSLDTKISSTTATAGTTSTCSSSWMKSPLWYDESSVNPRASSQVCGTEQSATFTLPTSFGIYKCNKHVVQLCYFVYENKTAFNTFGCGDYYQNYYDGNGNLIGGMDNRVAAYRGIAGAGVKIECPSKILRPGTYSIRSTPRFLLVPKRSYCFDTDGGYPIQVVQSEWSASRRSDNATEEACLQTEGCIFIKKTTPYVGEADDNHGDTEMRQLLSGLGSNDTVCVSQSGYTKGETPFVKDYLSPPKYGRCQLRTDSGRIPTLPSGLIIPQAGTDSLMRTLTPATRIFGIDDLIFGFLFIGFVAGGVAGGYFWGRSSAGGGGASVSSTQAGFDKIGKDIQQLRNDTNAAIEGFNGRIAHDEQAIKNLAKEIEDARAEALVGELGIIRSLIVANISMNLKESLYELANQITKRGGGIAQEAGPGCWYVDSENCDASCKEYIFNFNGSAPVPTVRTVDTSVVITSDPYYLGSTIALCLLGLVAIAAFVGVIWVCCKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC494108
EMBL· GenBank· DDBJ
BBM60897.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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