A0A678XDL2 · A0A678XDL2_SPOEX
- ProteinCarboxylic ester hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids694 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Rapidly hydrolyzes choline released into the synapse.
Catalytic activity
- acetylcholine + H2O = acetate + choline + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 313 | Acyl-ester intermediate | ||||
Sequence: S | ||||||
Active site | 439 | Charge relay system | ||||
Sequence: E | ||||||
Active site | 553 | Charge relay system | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | acetylcholinesterase activity | |
Biological Process | acetylcholine catabolic process | |
Biological Process | choline metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarboxylic ester hydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Noctuoidea > Noctuidae > Amphipyrinae > Spodoptera
Accessions
- Primary accessionA0A678XDL2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MRVVLAALTALAARALA | ||||||
Chain | PRO_5025711967 | 18-694 | Carboxylic ester hydrolase | |||
Sequence: GPHEHRARHHAPEHPPHFPAPAPPQPYRGHGEAVRYNPELDTILPRLEDHETSSKRAKFEDAETSSKRAKYDERFYSNHERADEEPMADEPQLGPDDDDPLVVRTRKGRVRGITLTAATGKKVDAWFGIPYAQKPVGDLRFRHPRPAESWGDEILNTTTLPHSCVQIIDTVFGDFPGAMMWNPNTDMQEDCLFINIVTPRPRPKNAAVMLWVFGGGFYSGTATLDVYDAKILVSEEKVVYVSMQYRVASLGFLFFDTPDVPGNAGLFDQLMALQWVKDNIAYFGGNPHNITLFGESAGAVSVSLHLLSPLSRNLFSQAIMQSGAATAPWAIISREESILRGIRLAEAVHCPHSRTDMGPMIECLRKKSPDELVNNEWGTLGICEFPFVPIIDGSFLDELPARSLAHQNFKKTNLLMGSNTEEGYYYILYYLTELFPKEENVGISREQYLQAVRELNPYVNDVGKQAIVFEYTDWLNPDDPIRNRNALDKMVGDYHFTCGVNEMAHRYAETGNNVFTYYYKHRSKNNPWPSWTGVMHGDEINYVFGEPLNPGKNYSPEEVEFSKRLMRYWANFARTGNPSINPSGESTKIYWPVHTATGREYLSLAVNSSTIGHGLRVKECAFWQKYLPQLMAATNKPEPPKNCTNSASPVKVPYEIFGVGVVIATGLAKTTMFKYIV |
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 17-49 | Disordered | ||||
Sequence: AGPHEHRARHHAPEHPPHFPAPAPPQPYRGHGE | ||||||
Compositional bias | 18-32 | Basic and acidic residues | ||||
Sequence: GPHEHRARHHAPEHP | ||||||
Compositional bias | 64-105 | Basic and acidic residues | ||||
Sequence: LEDHETSSKRAKFEDAETSSKRAKYDERFYSNHERADEEPMA | ||||||
Region | 64-118 | Disordered | ||||
Sequence: LEDHETSSKRAKFEDAETSSKRAKYDERFYSNHERADEEPMADEPQLGPDDDDPL | ||||||
Domain | 118-640 | Carboxylesterase type B | ||||
Sequence: LVVRTRKGRVRGITLTAATGKKVDAWFGIPYAQKPVGDLRFRHPRPAESWGDEILNTTTLPHSCVQIIDTVFGDFPGAMMWNPNTDMQEDCLFINIVTPRPRPKNAAVMLWVFGGGFYSGTATLDVYDAKILVSEEKVVYVSMQYRVASLGFLFFDTPDVPGNAGLFDQLMALQWVKDNIAYFGGNPHNITLFGESAGAVSVSLHLLSPLSRNLFSQAIMQSGAATAPWAIISREESILRGIRLAEAVHCPHSRTDMGPMIECLRKKSPDELVNNEWGTLGICEFPFVPIIDGSFLDELPARSLAHQNFKKTNLLMGSNTEEGYYYILYYLTELFPKEENVGISREQYLQAVRELNPYVNDVGKQAIVFEYTDWLNPDDPIRNRNALDKMVGDYHFTCGVNEMAHRYAETGNNVFTYYYKHRSKNNPWPSWTGVMHGDEINYVFGEPLNPGKNYSPEEVEFSKRLMRYWANFARTGNPSINPSGESTKIYWPVHTATGREYLSLAVNSSTIGHGLRVKECAFW |
Sequence similarities
Belongs to the type-B carboxylesterase/lipase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length694
- Mass (Da)78,047
- Last updated2020-06-17 v1
- ChecksumEC836E3A010AAFFD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 18-32 | Basic and acidic residues | ||||
Sequence: GPHEHRARHHAPEHP | ||||||
Compositional bias | 64-105 | Basic and acidic residues | ||||
Sequence: LEDHETSSKRAKFEDAETSSKRAKYDERFYSNHERADEEPMA |