A0A678TJ50 · A0A678TJ50_OMV

Function

function

Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.

Catalytic activity

  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
    EC:3.4.22.45 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

126652004006008001,0001,2001,4001,6001,8002,0002,2002,4002,600
TypeIDPosition(s)Description
Active site607For helper component proteinase activity
Active site681For helper component proteinase activity

GO annotations

AspectTerm
Cellular Componenthost cell cytoplasmic vesicle
Cellular Componentviral capsid
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionhelicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type peptidase activity
Molecular Functionstructural molecule activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

Accessions

  • Primary accession
    A0A678TJ50

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain123-266Peptidase S30
Domain599-722Peptidase C6
Domain1193-1345Helicase ATP-binding
Domain1364-1523Helicase C-terminal
Domain2002-2220Peptidase C4
Domain2486-2610RdRp catalytic

Sequence similarities

Belongs to the potyviridae genome polyprotein family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    2,665
  • Mass (Da)
    301,066
  • Last updated
    2020-06-17 v1
  • Checksum
    9066B1B57CBA132F
MAVTFSCNLNTDVSMFRNISFGTFPAEPTPIRMGQLLVKQAESQIEKAFAAIKTFPVVLPEREKLIVKRMRRNFPKEDATIEPQIVAQLTVPPTKQHEAPLVKGVKQATSVKQRKPSFKRKIVKNGNQIQKIIDQVIHIMKRKCGTIDIAGSSGSVRFKKTDYGTLPLVRVRHMARKLHTVDLAANTEAKKILQRISEIAQPRYNIETCFLKRGDSGLLIKKSRILGAFVSDNALDFIVVRGRSKYGIVDAVSKVSCEILRLTVHYSLSAQYFDAFSTEFLKHRVVTHEGPCERDIPLQTIGKLHAQLYQLFFTSGKITCLKCMNEIARRNGNNFIEPLLSGVNDLEKDLCETSLPHVQALMRAIAIEREKRQIDINVHADVLRIVNGREGEIFKMISRLNDALSKSGFGDQSALKSAHIELLQIARWCKNRSDINQSGSLQNFRNKISGKAHVNTALMCDNQLDTNGNFLWGKRGYHAKRFFANYFEKIDPRDGYVQHRVRKSPNGERELAIGNLLMSTNFEVLRQQLKGNAIESMGITEACVSKLNNNFLYSCCCATLDDGKPVLSDLKIPTKNHLVIGNTGDAKYVDLPTNDDEHLYIAKDGYCYVNIFLAMLVNVSEKDAKEFTKTMVRDLVVPKLGKWPKLIDVATACHLLSVFFPDTRNAELPRILVDHTNKTMHVVDSYGSLTTGYHVLKATTVNQLIGFASDELQSEMKDYYVGGGRQGVTAWDLTKVLIKGIYRPAHMREVIEQEPCLLALAILSPHMLMALFNSGSFDQAAKYWMGKDDSIVRLVAILEMLTKKVSMARLLVEQHQILEQHAQNVFNEVFDGFRTQMSYHVVTQALLVMKSRCESNEQLGNLGFFLHDKRTLEIFEKNYCNELAASWNELSWLEKLYASWQWSKAQRKLKESFVPLDEEGSNGVCRKSLQQFAECVKNKCKEARVGCCKRVKETCKSVRRKCIRSIFSLVNASIPDLIKVANLLAIITLLMGIINQAQIWLHVHQKYKMQKRRERQDQMDQAIHHAYLSLKQNDQLPTVEQFEDVVRKLGDEIWEHYETFWKNCDVVKFQAKNQQEQNLEKIIAFVTLLSMLYSTERSDSLFKILNKVKGVLGTIEGGVYHQLDDIQDIISEKNLTIDFSLDNEKQIDHTTFDVTFGDWWQQQLNTNRVVSHYRTGGYFMEFTRATCLEVCNKIQTTAQHEFLIRGGVGSGKSTGLPFHLSSKGQVLIIEPTRPLAENVCKQLKNEPFLVHPTLRMRGLVTCGSDAIDVMTSGYALHYLANARNLLNSYAYIIFDECHVLDSSAMAFYSLLKEMQFSGKILKVSATPPGRETEFTTMKTVSLATEESISFEAFVRQQGTGSNVDVVSKGDNILVYVASYNEVDSLSKLLTDKGYSVTKVDGRTMKVGSVEIRTRGSPLNKHFVVATNIIENGVTLDIDVVVDFGVKVCADIDIDNRMMIFKKTAVSYGERIQRLGRVGRVKEGHALRIGHTEKGITEIPTAVATDAAFLCFAYGLPVMTHNVTTSLLSNCTRKQATTMMQFELSPYFTVGLVRFNGTMHPIIHDMLKQYKLRDSEIHLSTLAVPFKHIGSWMTVSQYRAMGAKLELPEETRLPFYLKDIPDKVYEKLWKCVVDHRGDAGFGRLTTHCAAKVAYTLSTDPVAVPRTVTIINALIAQEQEKQAYFKTLQMQNCSVGSFSLASIANALRSRYAVDHTGDNIEILQRAKAQLLDFAASPVTAQDSEVLSNYGVLHVVQHQNTGAVSRALGLRGKWNGELLTRDLFVNGCVLSGGIWMIWQYFKGKFGEEVSHQGMGKRQRQKLKFRNTALGKLGREVHGDDGTIEHHFGEAYTAKGKAKGKHGTRGMGTKTRHFMNIYGFDPSEYTIVRYLDPLTGATQDENPLMAIDLVQERFAEIRSQLISEDKLERQAVKSNPGIQAFYMKNKSDAALKVDLTPHNPLLVTRMGNIAGFPENEFVLRQTGKAQSIKVTDVPTANDFDEVEHEGKNLNRGLRDYNVISNVVCRLTNESDGHSASLYGLGYGGYIITNRHLFKNNNGTLKVQSQHGDFIVKNTTQLKMTPVGKTDILIIRMPKDFPVLPRRLRFRAPSNEDKVCLIASNFQEKYVSSLVSETSSIYPVGNGEFWQHWISTKDGHCGLPLTSTRDGFIIGIHSLSTITNSKNFFASIPSNFEESYLDKLEQQSWVSNWKYNPNEVSWNGLKLQENKPDSIFKAMKEVSSLFSDSVYEQGQESGWLFRELKDNLKAVAILPNQLVTKHVVKGPCQCFMKYLNETPEAETFFRPLMGHYGKSVLSKEAFIRDIMKYSKPIVLGEVDFLKFEEGYNNVVRMFRSLGFATCQYVTDGMEIYKSLNLKAAVGAMYTGKKQQYFEGMSEEDIQKLVEASCFRLWSGKFGIWNGSLKAELRPIEKVRAGKTRTFTAAPLDTLLGAKVCVDDFNAQFYAKHIQAPWTVGICKYYRGWDEFMAKLPTGWLYCDADGSQFDSSLTPFLINSVLRLRLEFMEEWDIGEQMLSNLYTEIIYTPIATPDGTVVKKFRGNNSGQPSTVVDNTLMVVLAMNYSLAKLNISYEAMDSRIRYFANGDDLIIAVNPVGGEQILDSLQNSFSELGLNYDFNDRTYNKEQLSFMSHQALWDGDMYIPKIKAERVVSILE

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue2665

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY769753
EMBL· GenBank· DDBJ
AWJ64382.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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