A0A678TJ50 · A0A678TJ50_OMV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2665 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 607 | For helper component proteinase activity | ||||
Sequence: C | ||||||
Active site | 681 | For helper component proteinase activity | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasmic vesicle | |
Cellular Component | viral capsid | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | serine-type peptidase activity | |
Molecular Function | structural molecule activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Stelpaviricetes > Patatavirales > Potyviridae > Potyvirus
- Virus hosts
Accessions
- Primary accessionA0A678TJ50
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 123-266 | Peptidase S30 | ||||
Sequence: VKNGNQIQKIIDQVIHIMKRKCGTIDIAGSSGSVRFKKTDYGTLPLVRVRHMARKLHTVDLAANTEAKKILQRISEIAQPRYNIETCFLKRGDSGLLIKKSRILGAFVSDNALDFIVVRGRSKYGIVDAVSKVSCEILRLTVHY | ||||||
Domain | 599-722 | Peptidase C6 | ||||
Sequence: LYIAKDGYCYVNIFLAMLVNVSEKDAKEFTKTMVRDLVVPKLGKWPKLIDVATACHLLSVFFPDTRNAELPRILVDHTNKTMHVVDSYGSLTTGYHVLKATTVNQLIGFASDELQSEMKDYYVG | ||||||
Domain | 1193-1345 | Helicase ATP-binding | ||||
Sequence: KIQTTAQHEFLIRGGVGSGKSTGLPFHLSSKGQVLIIEPTRPLAENVCKQLKNEPFLVHPTLRMRGLVTCGSDAIDVMTSGYALHYLANARNLLNSYAYIIFDECHVLDSSAMAFYSLLKEMQFSGKILKVSATPPGRETEFTTMKTVSLATE | ||||||
Domain | 1364-1523 | Helicase C-terminal | ||||
Sequence: DVVSKGDNILVYVASYNEVDSLSKLLTDKGYSVTKVDGRTMKVGSVEIRTRGSPLNKHFVVATNIIENGVTLDIDVVVDFGVKVCADIDIDNRMMIFKKTAVSYGERIQRLGRVGRVKEGHALRIGHTEKGITEIPTAVATDAAFLCFAYGLPVMTHNVT | ||||||
Domain | 2002-2220 | Peptidase C4 | ||||
Sequence: GKNLNRGLRDYNVISNVVCRLTNESDGHSASLYGLGYGGYIITNRHLFKNNNGTLKVQSQHGDFIVKNTTQLKMTPVGKTDILIIRMPKDFPVLPRRLRFRAPSNEDKVCLIASNFQEKYVSSLVSETSSIYPVGNGEFWQHWISTKDGHCGLPLTSTRDGFIIGIHSLSTITNSKNFFASIPSNFEESYLDKLEQQSWVSNWKYNPNEVSWNGLKLQE | ||||||
Domain | 2486-2610 | RdRp catalytic | ||||
Sequence: WLYCDADGSQFDSSLTPFLINSVLRLRLEFMEEWDIGEQMLSNLYTEIIYTPIATPDGTVVKKFRGNNSGQPSTVVDNTLMVVLAMNYSLAKLNISYEAMDSRIRYFANGDDLIIAVNPVGGEQI |
Sequence similarities
Belongs to the potyviridae genome polyprotein family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,665
- Mass (Da)301,066
- Last updated2020-06-17 v1
- Checksum9066B1B57CBA132F
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 2665 | |||||
Sequence: E |