A0A674HVJ3 · A0A674HVJ3_TAEGU
- ProteinPeroxiredoxin-1
- GenePRDX1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids196 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
Catalytic activity
- a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
CHEBI:35924 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3= CHEBI:30879 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 52 | Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | thioredoxin peroxidase activity | |
Biological Process | cell redox homeostasis | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | leukocyte activation | |
Biological Process | removal of superoxide radicals |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxiredoxin-1
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674HVJ3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-165 | Thioredoxin | |||
Region | 174-196 | Disordered | |||
Compositional bias | 182-196 | Basic and acidic residues | |||
Sequence similarities
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length196
- Mass (Da)21,971
- Last updated2020-06-17 v1
- ChecksumACD1FC6DCC21FA68
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0ZCB9 | H0ZCB9_TAEGU | PRDX1 | 222 | ||
B5G0L9 | B5G0L9_TAEGU | PRDX1 | 199 | ||
A0A674G9T9 | A0A674G9T9_TAEGU | PRDX1 | 121 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 182-196 | Basic and acidic residues | |||
Keywords
- Technical term