A0A674HC22 · A0A674HC22_TAEGU
- ProteinNeurofascin
- GeneNFASC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1363 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | plasma membrane | |
Molecular Function | cell-cell adhesion mediator activity | |
Biological Process | axon guidance | |
Biological Process | brain development |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Sauropsida (sauropsids) > Sauria (diapsids) > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves (birds) > Neognathae > Passeriformes (song birds) > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674HC22
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1229-1250 | Helical | ||||
Sequence: WFIGLMCAIALLVLILLIVCFI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MIPRRAQVTCAGIAFALCLQHLVSA | ||||||
Chain | PRO_5025642165 | 26-1363 | ||||
Sequence: IEVPLDSNIQSELPQPPTITKQSIKDYIVDPRDNIFIECEAKGNPVPTFSWTRNGKFFNVAKDPKVSMRRRSGTLVIDFHSGGRPDDYEGEYQCFARNDYGTALSSKIHLQVSKSPLWPKEKVDVIEVDEGAPLSLQCNPPPGLPEPVIFWMSSSMEPIPQDKRVSQGHNGDLYFSNVLAQDALTDYSCNARFHFTHTIQQKNPYTLKVKTTRGITETTPSFMYPYGTSSSQMVLRGVDLLLECIASGVPAPDIMWYKKGGELPVGKTKLENFNKALRISNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPENLILAPGEDGRLVCRANGNPKPSIQWLVNGEPIESSPPNPSREVAGDTIVFRDTQIGSSAVYQCNASNEHGYLLANAFVSVLDVPPRILGPRNQLIRVIQNNRTRLDCPFFGSPIPTLRWFKNGQGNTLDGGNYKAHENGSLEMFMARKEDQGIYTCVATNILGKAEAQVRLEVKDPTRIVRGPEDQVVKRGTMPRLHCRVKHDPTLRLMVTWLKDDAPLYLGSRMKKEEDGLTIYGVTEKDQGDYTCVASTELDKDLAKAYLTVLAIPANRLRDLPKERPDRPRDLELTDLAERSVRLTWIPGDDNNSPITDYIVQFEEDRFQPGMWHNHSRYPGSVNSAVLSLSPYVNYQFRVIAVNDVGSSVPSLPSERYQTNGARPEINPTGVQGAGTQKNNMEITWTPLNATQAYGPNLRYIVRWRRRDPRGSWYNETVRGARHVVWNTPIYVPYEIKVQAENDFGRAPEPDTYIGYSGEDYPKAAPTDVRIRVLNSTAIALTWTRVHLDTIQGQLKEYRAYFWRDSSLLKNLWVSKKRQFVSFPGDRNRGTVSRLFPYSNYKLEMVVTNGRGDGPRSEMKEFPTPEGVPSSPRYLRIRQPNLEIINLEWDHPEHPNGIITGYTLRYQPFNGSRTGRTVVENLSPNQTRFTLQRSDPISRYRFVLRARTQVGEGEALVEESPALLDEATPSPEATGPPPTTVEETSPETSPETSPETSPTISPTISATISPTVSPTTTPTTTDTTTTTTTTTTTTTTTSTAASTAASTSAAAERAPAATTRHELAANGSSIWDIRAMANSNWANITWSHNFSAGTDFVVKYITSNKTEKSIPVKAQGPSSVQLADLTPGMMYKLWVFPIWSHPSEHSYITFTTSSAYTKNQVDIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVRDNKDEHLNPEDKNVEDGSFDYRSLESDEDNKPLPNSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-138 | Ig-like | ||||
Sequence: PTITKQSIKDYIVDPRDNIFIECEAKGNPVPTFSWTRNGKFFNVAKDPKVSMRRRSGTLVIDFHSGGRPDDYEGEYQCFARNDYGTALSSKIHLQVS | ||||||
Domain | 144-231 | Ig-like | ||||
Sequence: PKEKVDVIEVDEGAPLSLQCNPPPGLPEPVIFWMSSSMEPIPQDKRVSQGHNGDLYFSNVLAQDALTDYSCNARFHFTHTIQQKNPYT | ||||||
Domain | 245-333 | Ig-like | ||||
Sequence: PSFMYPYGTSSSQMVLRGVDLLLECIASGVPAPDIMWYKKGGELPVGKTKLENFNKALRISNVSEEDSGEYFCLASNKMGSIRHTISVR | ||||||
Domain | 338-425 | Ig-like | ||||
Sequence: PYWLDEPENLILAPGEDGRLVCRANGNPKPSIQWLVNGEPIESSPPNPSREVAGDTIVFRDTQIGSSAVYQCNASNEHGYLLANAFVS | ||||||
Domain | 431-520 | Ig-like | ||||
Sequence: PRILGPRNQLIRVIQNNRTRLDCPFFGSPIPTLRWFKNGQGNTLDGGNYKAHENGSLEMFMARKEDQGIYTCVATNILGKAEAQVRLEVK | ||||||
Domain | 522-604 | Ig-like | ||||
Sequence: PTRIVRGPEDQVVKRGTMPRLHCRVKHDPTLRLMVTWLKDDAPLYLGSRMKKEEDGLTIYGVTEKDQGDYTCVASTELDKDLA | ||||||
Domain | 628-723 | Fibronectin type-III | ||||
Sequence: RPRDLELTDLAERSVRLTWIPGDDNNSPITDYIVQFEEDRFQPGMWHNHSRYPGSVNSAVLSLSPYVNYQFRVIAVNDVGSSVPSLPSERYQTNGA | ||||||
Region | 711-733 | Disordered | ||||
Sequence: PSLPSERYQTNGARPEINPTGVQ | ||||||
Domain | 728-821 | Fibronectin type-III | ||||
Sequence: NPTGVQGAGTQKNNMEITWTPLNATQAYGPNLRYIVRWRRRDPRGSWYNETVRGARHVVWNTPIYVPYEIKVQAENDFGRAPEPDTYIGYSGED | ||||||
Domain | 826-928 | Fibronectin type-III | ||||
Sequence: APTDVRIRVLNSTAIALTWTRVHLDTIQGQLKEYRAYFWRDSSLLKNLWVSKKRQFVSFPGDRNRGTVSRLFPYSNYKLEMVVTNGRGDGPRSEMKEFPTPEG | ||||||
Region | 913-932 | Disordered | ||||
Sequence: GDGPRSEMKEFPTPEGVPSS | ||||||
Domain | 932-1028 | Fibronectin type-III | ||||
Sequence: SPRYLRIRQPNLEIINLEWDHPEHPNGIITGYTLRYQPFNGSRTGRTVVENLSPNQTRFTLQRSDPISRYRFVLRARTQVGEGEALVEESPALLDEA | ||||||
Region | 1014-1121 | Disordered | ||||
Sequence: GEALVEESPALLDEATPSPEATGPPPTTVEETSPETSPETSPETSPTISPTISATISPTVSPTTTPTTTDTTTTTTTTTTTTTTTSTAASTAASTSAAAERAPAATTR | ||||||
Compositional bias | 1038-1114 | Polar residues | ||||
Sequence: PPTTVEETSPETSPETSPETSPTISPTISATISPTVSPTTTPTTTDTTTTTTTTTTTTTTTSTAASTAASTSAAAER | ||||||
Compositional bias | 1259-1290 | Basic and acidic residues | ||||
Sequence: PVRDNKDEHLNPEDKNVEDGSFDYRSLESDED | ||||||
Region | 1259-1363 | Disordered | ||||
Sequence: PVRDNKDEHLNPEDKNVEDGSFDYRSLESDEDNKPLPNSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA | ||||||
Compositional bias | 1291-1311 | Polar residues | ||||
Sequence: NKPLPNSQTSLDGTIKQQESD | ||||||
Compositional bias | 1334-1348 | Basic and acidic residues | ||||
Sequence: QYTVKKDKEETEGNE | ||||||
Compositional bias | 1349-1363 | Polar residues | ||||
Sequence: SSEATSPVNAIYSLA |
Sequence similarities
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,363
- Mass (Da)151,950
- Last updated2020-06-17 v1
- Checksum59C1092FB4B83323
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674GT74 | A0A674GT74_TAEGU | NFASC | 1366 | ||
A0A674GR97 | A0A674GR97_TAEGU | NFASC | 1237 | ||
A0A674GMX7 | A0A674GMX7_TAEGU | NFASC | 1273 | ||
H1A4F5 | H1A4F5_TAEGU | NFASC | 1272 | ||
A0A674G7Q8 | A0A674G7Q8_TAEGU | NFASC | 1351 | ||
A0A674G7E9 | A0A674G7E9_TAEGU | NFASC | 1360 | ||
A0A674GW89 | A0A674GW89_TAEGU | NFASC | 1359 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1038-1114 | Polar residues | ||||
Sequence: PPTTVEETSPETSPETSPETSPTISPTISATISPTVSPTTTPTTTDTTTTTTTTTTTTTTTSTAASTAASTSAAAER | ||||||
Compositional bias | 1259-1290 | Basic and acidic residues | ||||
Sequence: PVRDNKDEHLNPEDKNVEDGSFDYRSLESDED | ||||||
Compositional bias | 1291-1311 | Polar residues | ||||
Sequence: NKPLPNSQTSLDGTIKQQESD | ||||||
Compositional bias | 1334-1348 | Basic and acidic residues | ||||
Sequence: QYTVKKDKEETEGNE | ||||||
Compositional bias | 1349-1363 | Polar residues | ||||
Sequence: SSEATSPVNAIYSLA |
Keywords
- Technical term