A0A674HAV6 · A0A674HAV6_TAEGU

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site32-38GTP (UniProtKB | ChEBI)
Active site33Proton acceptor
Binding site33Mg2+ (UniProtKB | ChEBI)
Binding site33substrate
Binding site33-36IMP (UniProtKB | ChEBI)
Binding site58-61IMP (UniProtKB | ChEBI)
Binding site60Mg2+ (UniProtKB | ChEBI)
Binding site60-62GTP (UniProtKB | ChEBI)
Active site61Proton donor
Binding site155IMP (UniProtKB | ChEBI)
Active site166
Binding site169IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site248IMP (UniProtKB | ChEBI)
Binding site263IMP (UniProtKB | ChEBI)
Binding site323-329substrate
Binding site327IMP (UniProtKB | ChEBI)
Binding site329GTP (UniProtKB | ChEBI)
Binding site355-357GTP (UniProtKB | ChEBI)
Binding site437-440GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase isozyme 2
  • EC number
  • Short names
    AMPSase 2
    ; AdSS 2
  • Alternative names
    • Adenylosuccinate synthetase, acidic isozyme
    • Adenylosuccinate synthetase, liver isozyme
      (L-type adenylosuccinate synthetase
      )
    • IMP--aspartate ligase 2

Gene names

    • Name
      ADSS2
    • Synonyms
      ADSS

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674HAV6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    49,407
  • Last updated
    2020-06-17 v1
  • Checksum
    AE137308F6BCD1D5
MAEHGGPGIPNGECAARRPGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDAVEYDFHLLPSGIINPKVTAFIGNGVVIHLPGLFEEAEKNLKKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDDFSERFKVLANQYKAIYPTLKIDIEGELEKLKGYMEKVKPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNIGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQQRGKEFGVTTGRKRRCGWLDLVSLRYVYMINGFTALALTKLDILDVFPEIKIGVAYKLDGEIIPHFPANHEVLNKVEVQYETLPGWVTDISNARTFDELPVNAQNYVRFIEMELGVPVKWIGVGKSRESMIQLF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0ZD71H0ZD71_TAEGUADSS463
H0ZZG5H0ZZG5_TAEGUADSS2429

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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