A0A674H6Z3 · A0A674H6Z3_TAEGU
- ProteinTyrosine-protein kinase receptor
- GeneNTRK2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids758 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 540-548 | ATP (UniProtKB | ChEBI) | |||
Binding site | 568 | ATP (UniProtKB | ChEBI) | |||
Active site | 672 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon terminus | |
Cellular Component | dendritic spine | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic density | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | brain-derived neurotrophic factor binding | |
Molecular Function | brain-derived neurotrophic factor receptor activity | |
Biological Process | cell differentiation | |
Biological Process | cellular response to brain-derived neurotrophic factor stimulus | |
Biological Process | nervous system development | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | trans-synaptic signaling by neuropeptide, modulating synaptic transmission |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674H6Z3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 427-450 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-31 | ||||
Chain | PRO_5025466697 | 32-758 | Tyrosine-protein kinase receptor | ||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 196-281 | Ig-like | |||
Region | 400-420 | Disordered | |||
Compositional bias | 401-420 | Polar residues | |||
Compositional bias | 469-492 | Polar residues | |||
Region | 469-494 | Disordered | |||
Domain | 534-758 | Protein kinase | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length758
- Mass (Da)84,126
- Last updated2020-06-17 v1
- ChecksumB5412B5554EA7668
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674GFH4 | A0A674GFH4_TAEGU | NTRK2 | 842 | ||
H0YY17 | H0YY17_TAEGU | NTRK2 | 808 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 401-420 | Polar residues | |||
Compositional bias | 469-492 | Polar residues | |||
Keywords
- Technical term