A0A674H3P5 · A0A674H3P5_TAEGU

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site72-75CoA (UniProtKB | ChEBI)
Binding site98CoA (UniProtKB | ChEBI)
Binding site151-153CoA (UniProtKB | ChEBI)
Binding site215substrate; ligand shared with subunit beta
Active site307Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex (ADP-forming)
Molecular Functionnucleotide binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit alpha
      (SCS-alpha
      )

Gene names

    • Name
      SUCLG1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674H3P5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain59-155CoA-binding

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    37,258
  • Last updated
    2020-06-17 v1
  • Checksum
    6834EE2A147D21F3
MSRCSPAAARLLGRFLRRPFSVSHCHSPGSLECSPQGLAGVQQNGVRHCSYTASRKNLYVNKNTKVICQGFTGKQGTFHSQQALEYGTNLVGGISPGKGGKTHLGLPVFNSVKEAKEQTGASATVIYVPPPFAAAAINEAIDAEMPLVVCITEGIPQQDMVRVKHRLLRQNKTRLVGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSFCVGIGGDPFNGTNFIDCLDVFLKDPRTEGIILIGEIGGNAEEDAAAFLKENNAGPNAKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKIAALQSAGVVVSMSPAQLGSTIYKEFEKRKLL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A674H1J9A0A674H1J9_TAEGUSUCLG1412
H0ZKW8H0ZKW8_TAEGUSUCLG1331
A0A674H950A0A674H950_TAEGUSUCLG1397

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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