A0A674H365 · A0A674H365_TAEGU

Function

function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

Catalytic activity

Pathway

Sulfur metabolism; glutathione metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site105L-glutamate (UniProtKB | ChEBI)
Active site380Nucleophile
Binding site398-400L-glutamate (UniProtKB | ChEBI)
Binding site422L-glutamate (UniProtKB | ChEBI)
Binding site450-451L-glutamate (UniProtKB | ChEBI)
Binding site473L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionacyltransferase activity
Molecular Functionglutathione hydrolase activity
Biological Processglutathione catabolic process
Biological Processpeptide modification
Biological Processregulation of immune system process
Biological Processregulation of inflammatory response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione hydrolase
  • EC number
  • Alternative names
    • Gamma-glutamyltransferase
    • Gamma-glutamyltranspeptidase

Gene names

    • Name
      GGT1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674H365

Proteomes

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-28Helical

Keywords

  • Cellular component

Family & Domains

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    567
  • Mass (Da)
    61,096
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    B7B6781D46A1199C5DFAACFC03795558
MKTRCVVVAVVAVALLGLVLFLGLFFGLRSGDTHTYRRAAVATDAGPCSIIGSRDILKQGGSAVDAAIAALLCVGLMNAHSMGIGGGLFFTIYNSTGKVEIINAREVAPKNASEDMFGNNTQLSLKGGLSIAVPGEIRGYELAHKRHGKLAWKDLFLPSIKLAKEGFPVGKGLAAAIKSKEEAIESNPLLCEVFCKGGRILQEGETIKMPKLANTYNTIASEGADAFYTGSLAKQIIADIHNAGGIVTLEDLRNYNATVIEDPIQIKLGEFTLYTPSAPLSGPVLALILNILKGYNFSAASIKTVEEKGLTYHRIVEAFRFAYAKRTLLGDPKFVNITEAIRNMTSEFFADSLRRKITDNTSHPVDYYEPVYYTGDNAGTSHVSIVADDGSAVSATSTINQYFGSDVRSSVSGIIFNDEMDDFSSPYIINGFGIPPSPANFIAPGKQPMSSMCPSILVDKMKQVRMVVGASGGTKITTATALTIMNSIWFGYDVKKAVEEPRIHDQLFPNITELEQQIEEGIEQQLRRRRHDTARVSGGAVVQAILRTERGWAAASDSRKGGFPAGY

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A674GY64A0A674GY64_TAEGUGGT1607
A0A674HTD5A0A674HTD5_TAEGUGGT1546
H0ZIK1H0ZIK1_TAEGUGGT1573
A0A674GE95A0A674GE95_TAEGUGGT1588

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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