A0A674H307 · A0A674H307_TAEGU
- ProteinAldo-keto reductase family 1 member B1
- GeneAKR1B1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids319 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- (E)-hex-2-en-1-ol + NADP+ = (E)-hex-2-enal + NADPH + H+
- (E,E)-2,4-hexadien-1-ol + NADP+ = (E,E)-2,4-hexadienal + NADPH + H+
- 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + NADPH + H+ = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP+
- 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + NADPH + H+ = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP+
- 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + NADPH + H+ = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP+
- 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + NADPH + H+ = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP+
- 13-cis-retinol + NADP+ = 13-cis-retinal + NADPH + H+
- 9-cis-retinol + NADP+ = 9-cis-retinal + NADPH + H+
- prenol + NADP+ = 3-methyl-2-butenal + NADPH + H+
- prostaglandin F2alpha + NADP+ = prostaglandin H2 + NADPH + H+
- a 4-hydroxynonen-1-ol + NADP+ = a 4-hydroxynonenal + NADPH + H+
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 52 | Proton donor | |||
Site | 81 | Lowers pKa of active site Tyr | |||
Binding site | 114 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aldose reductase (NADPH) activity |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldo-keto reductase family 1 member B1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674H307
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length319
- Mass (Da)35,809
- Last updated2020-06-17 v1
- MD5 Checksum68B833CBC71A16858CC90A053D859619
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674H5F5 | A0A674H5F5_TAEGU | AKR1B1 | 321 | ||
A0A674HQU9 | A0A674HQU9_TAEGU | AKR1B1 | 319 | ||
A0A674G955 | A0A674G955_TAEGU | AKR1B1 | 317 | ||
A0A674H963 | A0A674H963_TAEGU | AKR1B1 | 319 | ||
A0A674H3T4 | A0A674H3T4_TAEGU | AKR1B1 | 314 |
Keywords
- Technical term