A0A674H307 · A0A674H307_TAEGU

Function

Catalytic activity

  • (E)-hex-2-en-1-ol + NADP+ = (E)-hex-2-enal + NADPH + H+
  • (E,E)-2,4-hexadien-1-ol + NADP+ = (E,E)-2,4-hexadienal + NADPH + H+
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + NADPH + H+ = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + NADPH + H+ = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP+
  • 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + NADPH + H+ = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + NADPH + H+ = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP+
  • 13-cis-retinol + NADP+ = 13-cis-retinal + NADPH + H+
  • 9-cis-retinol + NADP+ = 9-cis-retinal + NADPH + H+
  • prenol + NADP+ = 3-methyl-2-butenal + NADPH + H+
  • prostaglandin F2alpha + NADP+ = prostaglandin H2 + NADPH + H+
  • a 4-hydroxynonen-1-ol + NADP+ = a 4-hydroxynonenal + NADPH + H+
  • all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+
    EC:1.1.1.300 (UniProtKB | ENZYME | Rhea)
  • an alditol + NADP+ = an aldose + NADPH + H+
    EC:1.1.1.21 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site, site, binding site.

Type
IDPosition(s)Description
Active site52Proton donor
Site81Lowers pKa of active site Tyr
Binding site114substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaldose reductase (NADPH) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldo-keto reductase family 1 member B1
  • EC number
  • Alternative names
    • Aldose reductase

Gene names

    • Name
      AKR1B1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674H307

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-295NADP-dependent oxidoreductase

Sequence similarities

Belongs to the aldo/keto reductase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    319
  • Mass (Da)
    35,809
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    68B833CBC71A16858CC90A053D859619
MAGMAGYARLGAAGSVPLMGLGTWKSPPGKVAAAVTAAIDAGYRHFDCAYVYQNEKEVGEGIQQKIKEGAVKREDLFVVSKLWCTFHERPLVKAACQKSLADLKLGYLDLYLVHWPFGFKAGEDLFPVDDKGMAISSNTDILQTWEAMEELVDAGLVKAIGISNFNHEQIERILNKPGLKYKPANNQVECHPYLTQEKLIKYCQSKGIAVTAYSPLGSPDRPWAKTEDPSLLDDPKIKEIAAKHNKTPAQVLIRFHIQRNVIVIPKSVTPQRIVENFQVFDFELTKEEMATILSFNRNWRVCEMLMCKTHKGYPFNAEY

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A674H5F5A0A674H5F5_TAEGUAKR1B1321
A0A674HQU9A0A674HQU9_TAEGUAKR1B1319
A0A674G955A0A674G955_TAEGUAKR1B1317
A0A674H963A0A674H963_TAEGUAKR1B1319
A0A674H3T4A0A674H3T4_TAEGUAKR1B1314

Keywords

Genome annotation databases

Similar Proteins

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