A0A674GX26 · A0A674GX26_TAEGU

Function

Catalytic activity

  • (S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L-phenylalanine
    This reaction proceeds in the forward
    and the backward
    directions.
  • H2O + L-cysteinylglycine = glycine + L-cysteine
    This reaction proceeds in the forward direction.
  • H2O + L-seryl-L-threonine = L-serine + L-threonine
    This reaction proceeds in the forward direction.
  • H2O + L-threonyl-L-serine = L-serine + L-threonine
    This reaction proceeds in the forward direction.
  • H2O + L-threonyl-L-threonine = 2 L-threonine
    This reaction proceeds in the forward direction.
  • Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
    EC:3.4.13.18 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site99Mn2+ 2 (UniProtKB | ChEBI)
Active site101
Binding site132Mn2+ 1 (UniProtKB | ChEBI)
Binding site132Mn2+ 2 (UniProtKB | ChEBI)
Active site165Proton acceptor
Binding site166Mn2+ 1 (UniProtKB | ChEBI)
Binding site194Mn2+ 2 (UniProtKB | ChEBI)
Binding site194substrate; ligand shared between homodimeric partners; in other chain
Binding site227substrate; ligand shared between homodimeric partners
Site227Important for catalytic activity
Binding site329substrate; ligand shared between homodimeric partners
Binding site342substrate; ligand shared between homodimeric partners; in other chain
Binding site416substrate; ligand shared between homodimeric partners; in other chain
Binding site444Mn2+ 1 (UniProtKB | ChEBI)
Binding site444substrate; ligand shared between homodimeric partners; in other chain

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncarboxypeptidase activity
Molecular Functionmetal ion binding
Molecular Functionmetallodipeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytosolic non-specific dipeptidase
  • EC number
  • Alternative names
    • CNDP dipeptidase 2
    • Threonyl dipeptidase

Gene names

    • Name
      CNDP2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674GX26

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain207-366Peptidase M20 dimerisation

Sequence similarities

Belongs to the peptidase M20A family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    52,958
  • Last updated
    2020-06-17 v1
  • Checksum
    487C84388BDC425A
MSALETLFKYIDEHQDLYVQRLAEWVAIQSVSAWPEKRGEIKHMMEVAAKEIERLGGTTKLMDIGKQKLPDGSEIPLPPIVLGTLGTDPRKKTVCVYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVLAWLNALEAYQQTNQFPVNIRFCLEGMEESGSEGLDELIFAQRDAFFKDVDYVCISDNYWLGKKKPCITYGLRGVCYYFIEVECCDKDLHSGVYGGSVHEAMTDLIALMGSLVDGKGKILIPGVNEAVAPVTDEELALYEKIDFDLTEYAKDVGATRLLHDAKREILMHRWRYPSLSLHGIEGAFSASGAKTVIPRKVIGKFSIRLVPNMTPEEVTKNVEDYLNKKFAELQSPNKFKVYLGHGGKPWVSDFNHPHYMAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGAADDGAHSQNEKLNRYNYIQGVKMLGAYLYEVSQLKD

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A674GXZ8A0A674GXZ8_TAEGUCNDP2511
H0ZFS7H0ZFS7_TAEGUCNDP2475
A0A674H3U3A0A674H3U3_TAEGUCNDP2454

Keywords

Genome annotation databases

Similar Proteins

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