A0A674GWE8 · A0A674GWE8_TAEGU
- ProteinDNA 3'-5' helicase
- GeneWRN
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1439 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | 3'-5' exonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | isomerase activity | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA 3'-5' helicase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674GWE8
Proteomes
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 438-458 | Basic and acidic residues | ||||
Sequence: EGVLPEGESSKARKTPDTEVD | ||||||
Region | 438-470 | Disordered | ||||
Sequence: EGVLPEGESSKARKTPDTEVDVAADGDEDEGIE | ||||||
Domain | 510-676 | Helicase ATP-binding | ||||
Sequence: NSLLEDRRDNLVVMATGYGKSLCYQFPPVYTGHTGVVICPLISLMEDQVLQLTMTGIPACFLGSAQSKQVKDSIRGGQYRVIYMTPEFCSGNLQLLRDLNQTVGITLIAVDEAHCISEWGHDFRSSFRNLGILKKALPLVPIIALTATASPSIREDIVKCLDLRNPQ | ||||||
Domain | 701-858 | Helicase C-terminal | ||||
Sequence: DLKQFLIRKGSSSVYEFEGPTIIYCPTRKATEQVVCALNKLNVACGTYHAGMESKQRRDTHHQFMRDEIQCVVATVAFGMGINKADIRLVIHYGAPKEMESYYQEMGRAGRDGLPAACHVLWAATDLVSNRRLLGEIRNEAFRLYKLKMLEKMEKYLV | ||||||
Region | 1008-1055 | Disordered | ||||
Sequence: NDGSSSNPSLLLQSSEDLNLERPSASSRRSPLLSRQRSPGTKGTAQSP | ||||||
Domain | 1106-1185 | HRDC | ||||
Sequence: KELETALYGKLLTARQKVANEKEIPPAVLATNKILVEMARIRPTNIENLKKIDGVSEAKSTMLMPLLAEIKDFCQANGLQ | ||||||
Region | 1332-1412 | Disordered | ||||
Sequence: GQQGKTGADQASREGASWNKKQAAGSVDASQAGSRGPAGPSKPITLATSKQPALDPEEEELFADSQPKNSHPPAKRRVPEW | ||||||
Compositional bias | 1336-1360 | Polar residues | ||||
Sequence: KTGADQASREGASWNKKQAAGSVDA | ||||||
Compositional bias | 1384-1406 | Basic and acidic residues | ||||
Sequence: ALDPEEEELFADSQPKNSHPPAK |
Sequence similarities
Belongs to the helicase family. RecQ subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,439
- Mass (Da)159,083
- Last updated2020-06-17 v1
- Checksum818E1334651E4F3D
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0YU56 | H0YU56_TAEGU | WRN | 1449 | ||
A0A674GK55 | A0A674GK55_TAEGU | WRN | 1432 | ||
A0A674HV39 | A0A674HV39_TAEGU | WRN | 1448 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 438-458 | Basic and acidic residues | ||||
Sequence: EGVLPEGESSKARKTPDTEVD | ||||||
Compositional bias | 1336-1360 | Polar residues | ||||
Sequence: KTGADQASREGASWNKKQAAGSVDA | ||||||
Compositional bias | 1384-1406 | Basic and acidic residues | ||||
Sequence: ALDPEEEELFADSQPKNSHPPAK |
Keywords
- Technical term