A0A674GSA8 · A0A674GSA8_TAEGU
- ProteinHistone-lysine N-methyltransferase SETDB2
- GeneSETDB2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids721 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine + H+
RHEA-COMP:15541 CHEBI:61976 Position: 9+ CHEBI:59789 = RHEA-COMP:15538 CHEBI:61961 Position: 9+ CHEBI:57856 + CHEBI:15378
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | histone H3K9 methyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | cell division | |
Biological Process | heterochromatin organization | |
Biological Process | negative regulation of gene expression | |
Biological Process | positive regulation of DNA methylation-dependent heterochromatin formation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase SETDB2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674GSA8
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 94-131 | Disordered | |||
Compositional bias | 117-131 | Basic and acidic residues | |||
Domain | 301-375 | Pre-SET | |||
Domain | 378-696 | SET | |||
Compositional bias | 514-535 | Polar residues | |||
Region | 514-553 | Disordered | |||
Compositional bias | 536-553 | Basic and acidic residues | |||
Region | 599-630 | Disordered | |||
Compositional bias | 607-623 | Basic and acidic residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length721
- Mass (Da)80,559
- Last updated2020-06-17 v1
- ChecksumB7A320982BD8604B
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674H040 | A0A674H040_TAEGU | SETDB2 | 698 | ||
H0ZPI9 | H0ZPI9_TAEGU | SETDB2 | 689 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 117-131 | Basic and acidic residues | |||
Compositional bias | 514-535 | Polar residues | |||
Compositional bias | 536-553 | Basic and acidic residues | |||
Compositional bias | 607-623 | Basic and acidic residues | |||
Keywords
- Technical term