A0A674GM26 · A0A674GM26_TAEGU
- ProteinMitogen-activated protein kinase kinase kinase
- GeneMAP3K21
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1070 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Homodimerization via the leucine zipper domains is required for autophosphorylation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 115-123 | ATP (UniProtKB | ChEBI) | |||
Binding site | 136 | ATP (UniProtKB | ChEBI) | |||
Active site | 243 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674GM26
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 20-84 | SH3 | |||
Domain | 109-381 | Protein kinase | |||
Coiled coil | 405-432 | ||||
Region | 498-530 | Disordered | |||
Compositional bias | 499-530 | Polar residues | |||
Region | 707-739 | Disordered | |||
Compositional bias | 712-738 | Polar residues | |||
Region | 797-821 | Disordered | |||
Region | 854-873 | Disordered | |||
Region | 949-981 | Disordered | |||
Compositional bias | 950-981 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,070
- Mass (Da)118,903
- Last updated2020-06-17 v1
- Checksum477CAD91CE04C972
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0ZIV1 | H0ZIV1_TAEGU | MAP3K21 | 1023 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 499-530 | Polar residues | |||
Compositional bias | 712-738 | Polar residues | |||
Compositional bias | 950-981 | Polar residues | |||
Keywords
- Technical term