A0A674GLV8 · A0A674GLV8_TAEGU
- ProteinPhosphodiesterase
- GenePDE2A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids949 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 644 | Proton donor | |||
Binding site | 644-648 | AMP (UniProtKB | ChEBI) | |||
Binding site | 648 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 684 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 685 | AMP (UniProtKB | ChEBI) | |||
Binding site | 685 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 685 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 796 | AMP (UniProtKB | ChEBI) | |||
Binding site | 796 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 833 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial matrix | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | synaptic membrane | |
Molecular Function | 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | |
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | cAMP-mediated signaling | |
Biological Process | cGMP catabolic process | |
Biological Process | cGMP-mediated signaling | |
Biological Process | negative regulation of cAMP-mediated signaling | |
Biological Process | negative regulation of cGMP-mediated signaling | |
Biological Process | positive regulation of gene expression | |
Biological Process | regulation of mitochondrion organization |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674GLV8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-23 | ||||
Chain | PRO_5025595626 | 24-949 | Phosphodiesterase | ||
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 566-837 | PDEase | |||
Region | 850-878 | Disordered | |||
Region | 911-949 | Disordered | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length949
- Mass (Da)106,065
- Last updated2020-06-17 v1
- MD5 Checksum1AF1055D598503FD4E5898E1FBDAE489
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674HT90 | A0A674HT90_TAEGU | PDE2A | 939 | ||
A0A674H4W0 | A0A674H4W0_TAEGU | PDE2A | 865 | ||
H0ZTM6 | H0ZTM6_TAEGU | PDE2A | 940 |
Keywords
- Technical term