A0A674GLV8 · A0A674GLV8_TAEGU

Function

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

1949100200300400500600700800900
Type
IDPosition(s)Description
Active site644Proton donor
Binding site644-648AMP (UniProtKB | ChEBI)
Binding site648Zn2+ 1 (UniProtKB | ChEBI)
Binding site684Zn2+ 1 (UniProtKB | ChEBI)
Binding site685AMP (UniProtKB | ChEBI)
Binding site685Zn2+ 2 (UniProtKB | ChEBI)
Binding site685Zn2+ 1 (UniProtKB | ChEBI)
Binding site796AMP (UniProtKB | ChEBI)
Binding site796Zn2+ 1 (UniProtKB | ChEBI)
Binding site833AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrial outer membrane
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular Componentsynaptic membrane
Molecular Function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Function3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Biological ProcesscAMP-mediated signaling
Biological ProcesscGMP catabolic process
Biological ProcesscGMP-mediated signaling
Biological Processnegative regulation of cAMP-mediated signaling
Biological Processnegative regulation of cGMP-mediated signaling
Biological Processpositive regulation of gene expression
Biological Processregulation of mitochondrion organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      PDE2A

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674GLV8

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-23
ChainPRO_502559562624-949Phosphodiesterase

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain566-837PDEase
Region850-878Disordered
Region911-949Disordered

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    949
  • Mass (Da)
    106,065
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    1AF1055D598503FD4E5898E1FBDAE489
MVPRLLIALLRFFSRGFLRAGDAAPGPEALQDALLSLGAALDATTLRDALRHALVTLLPAVEHVYIYLLDGDTRLLCDDPPHELPHNGKLRDAVQKQKRLECGGLLPAELPGRHLGPLAAPLAPGTQVLIIPLVDKNCGAVVCVILVHCGQLSDSDEQNLHALERHALVAFRRLQALQKLQPWPQVSLSTSSSQTSLAKPEKAPDSSYNDLDCKILQLCGELYDLDAASLQLKVINYLKQETQSLCCCLLLVSEDNHQLFCQVVGDRVLDEEISFSLTFGRLGQVVEDKKPITLKDISEEEHKQLSSMLGCEVTSMLCVPVISRATSQVVALACAFNKLSGESYTDTDEHKIQHCFCYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDRLSHELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGKILNIKDAYSHPLFYRGVDDSTGFRTRNILCFPIKNESQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLSEGIQPVSTIDPNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKMDRQTLTRFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELVNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNSQGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDPKNKQHRSLLLCLLMTSCDLSDQTKGWKTTRKIAKAMGNSPLEMMDREKAYIPELQISFMEHIAMPIYKISSPRQRSSTSGWPATGSSGPRSPTNSPSGGCPVTTPWTFWMRNMTHRSLTPSSMAAWNLRWGSPPRLGPSEEGDGGPQPWLGWEHPQASSPSLWGGGLGGYR

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A674HT90A0A674HT90_TAEGUPDE2A939
A0A674H4W0A0A674H4W0_TAEGUPDE2A865
H0ZTM6H0ZTM6_TAEGUPDE2A940

Keywords

Genome annotation databases

Similar Proteins

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