A0A674GGB5 · A0A674GGB5_TAEGU

Function

function

Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function5'-flap endonuclease activity
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA repair
Biological ProcessDNA replication, Okazaki fragment processing
Biological Processreplication fork reversal

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication ATP-dependent helicase/nuclease
  • EC number

Gene names

    • Name
      DNA2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674GGB5

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain53-258DNA replication factor Dna2 N-terminal
Domain447-543DNA2 rift barrel
Domain603-701DNA2/NAM7 helicase helicase
Domain709-768DNA2/NAM7 helicase helicase
Domain777-985DNA2/NAM7 helicase-like C-terminal

Sequence similarities

Belongs to the DNA2/NAM7 helicase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,018
  • Mass (Da)
    114,473
  • Last updated
    2020-06-17 v1
  • Checksum
    66C86FA9AE2867B5
MAESFQKKVSDLPDTILKNGLNNRYRVLEVSIIQRNGSDPEKHLTITASPSLEDTELCILRSGWESVPVVPGDIVHLEGECSSGTWVVSAQSGYLVLYPDLLLSGTTISSSIRCMRRAVLSERFRGSESGSHQMLVGTILHDIFQQSVTNNLTQEKVQELANKIVYGQKYLKEMYLLNLKQAQIMQEVEEYLPSFFKWAEDFMHNPANQNKMQLKLSNGGKTEDVSSKIEVVDILDIEETIWSPRFGLKGKIDVTARVKIHCQSGVQSRIMPLELKSGKESNSIEHRSQVILYTLLNLERRVDPEAGFLLYLKTGTMYPVSGARMDRRELMKLRNHVAFYLTHSTYKSGVGRQNSQLAALPPVIDDSQTCKYCSQMQNCFLYSRAVEQKMESVAFPPALVPVIDRETQHLKPSHLEYFSLWYLMLTLELQSGEHKKGYKNIWMTPSLEKEKAGDCVGNMIRVDEVREVSEGHYLHFFQRRNGAIPGTNLLVGDRVVVSGEEKGLLGLATGYVREVSGTKVSCLLGRNLSNLPKDTVFRLDHDEGDVGTGVPFKNLSKLMKDCPVSERLRNLIIDFQKPRFIQHLSSVLPPEAKETVANILKGLNKPQKQAMKQVLLSKDYTLIVGMPGTGKTTTICALVRILSACGFSVLLTSFTHTAVDNVLLKLAKFKVGFLRLGQAQKVHPDIQKYTEEEICRSRSIKSVTDLEEPVVATSCMGVNHPIFVQKQFDFCIVDEASQISQLVCLGPLFCSKRFVLVGDHQQLPPLVLNAEARDLGMSESLFKRLEQNQNAVVQLTVQYRMNSKIMSLSNMLVYEGKLECGSEKVSNATVNLPNLKKLKLDFGDASKTWLKEVLDPDTPVCFLNTEKVPAPEHAEKGGISNVTEAKIVLFLTSLFIKAGCKPSDIGIISPYRHQLKTITDLMAKWKENRVEVNTVDKYQGRDKSIIIVSFVRNSIDENLGSLLKDWRRLNVAITRAKHKLVMVGCVPSLCCYPPLEKLLCHLQSQAMISFFSMLIWER

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H0YZU9H0YZU9_TAEGUDNA21021

Keywords

Genome annotation databases

Similar Proteins

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