A0A674GE95 · A0A674GE95_TAEGU
- ProteinGlutathione hydrolase
- GeneGGT1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids588 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 126 | L-glutamate (UniProtKB | ChEBI) | |||
Active site | 401 | Nucleophile | |||
Binding site | 419-421 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 443 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 471-472 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 494 | L-glutamate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | acyltransferase activity | |
Molecular Function | glutathione hydrolase activity | |
Biological Process | glutathione catabolic process | |
Biological Process | peptide modification | |
Biological Process | regulation of immune system process | |
Biological Process | regulation of inflammatory response |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674GE95
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 28-50 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length588
- Mass (Da)63,332
- Last updated2020-06-17 v1
- MD5 ChecksumDFB61C4B85E05D2CE9C29AC3B1AA2429
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674GY64 | A0A674GY64_TAEGU | GGT1 | 607 | ||
A0A674HTD5 | A0A674HTD5_TAEGU | GGT1 | 546 | ||
A0A674H365 | A0A674H365_TAEGU | GGT1 | 567 | ||
H0ZIK1 | H0ZIK1_TAEGU | GGT1 | 573 |
Keywords
- Technical term