A0A674GCU0 · A0A674GCU0_TAEGU
- ProteinTyrosine-protein kinase receptor
- GeneNTRK3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids826 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 517 | Interaction with SHC1 | |||
Binding site | 545-553 | ATP (UniProtKB | ChEBI) | |||
Binding site | 573 | ATP (UniProtKB | ChEBI) | |||
Active site | 680 | Proton acceptor | |||
Site | 821 | Interaction with PLCG1 | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | neurotrophin binding | |
Molecular Function | neurotrophin receptor activity | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | cellular response to nerve growth factor stimulus | |
Biological Process | nervous system development | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionA0A674GCU0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-31 | Helical | |||
Transmembrane | 431-454 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 209-299 | Ig-like | |||
Domain | 539-815 | Protein kinase | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length826
- Mass (Da)93,200
- Last updated2020-06-17 v1
- MD5 ChecksumC1A1143A00D848A4E409FE9C5FAB9DFA
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674GNM7 | A0A674GNM7_TAEGU | NTRK3 | 852 | ||
H0ZDH2 | H0ZDH2_TAEGU | NTRK3 | 849 | ||
A0A674GXC2 | A0A674GXC2_TAEGU | NTRK3 | 827 | ||
A0A674H6L7 | A0A674H6L7_TAEGU | NTRK3 | 819 |
Keywords
- Technical term