A0A674GCJ2 · A0A674GCJ2_TAEGU

Function

function

Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionhydrolase activity
Molecular Functionlipoprotein particle receptor binding
Molecular Functionmetal ion binding
Biological Processcentral nervous system development
Biological Processneuron migration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Reelin

Gene names

    • Name
      RELN

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    A0A674GCJ2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-27
ChainPRO_502559288028-3446Reelin
Disulfide bond2120↔2130
Disulfide bond2138↔2147
Disulfide bond3219↔3229
Disulfide bond3237↔3246

Keywords

Interaction

Subunit

Oligomer of disulfide-linked homodimers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-191Reelin
Domain2116-2148EGF-like
Domain3215-3247EGF-like

Sequence similarities

Belongs to the reelin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,446
  • Mass (Da)
    385,974
  • Last updated
    2020-06-17 v1
  • Checksum
    C6D960F45C2CFE35
MERRRGVPGGWPCLLAALGALLAAGRAAAPRARFSPFFFLCTHHGELEGDGEQGEVLIALHIAGNPAAYVPGQEYHVTISTSTFFDGLLVTGLYTSTSVQASQSVGGSSAFGFGIMSDHQFGNQFMCSVVASHVSHLPTTNLSFVWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLCEQGAPTEAPLHPHLAEMHSDSIILRDDFDSYDQQELNPAMWSECSNCEVGGHCGVIMHGNAATFCEPYGPREIIYASLCCNTSHFIVFPGSGSCRFSYSDPSITVSYSKNSSADWTQLEKISAPSNISTIIHILYLPEDAKGENIHFQWKQDYVLAGDVYEACWALDNILIINAAHRKVVLEDNLDPVDTGNWLFFPGATVKHSCQSDGNSIYFHGTEGSEFNFATTRDVDLSIEDAQEQWTEEFESQPKGWDIFGAVIGTECGTLESGSAMVFLRDGERKICTPYMDTTGYGNLRFYFSMGGACDSGESHENDVILYAKIEGRREHIPLDTLTYSAYKVPSLVSVVISPDLQTPATKFCLKQKSHQGHNRNVWAVDYFHVLPVLPSSMTHMIQFSINLGCGTYQPGNSVSLEFSTNHGRSWSLLHQECLPEICAGPHLPHSTIYASENYSGWNRITIPLPNAALTSDTRIRWRQTGPILGNMWAIDNIYIGPSCLKFCSGRGQCTRNGCKCDPGFSGPACEMASQTFPMFISESFASSRLSSYHSFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCKAPDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPEDARQVGIQFRWWQPYHSSQGEDVWAIDEIIMTSVLFNSISLDFTNLVEVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFNLVMGCGQAFTPHMDNQVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHSSEFTQWRRITVLLPQKTWSSATRFRWSQCYYTAQDEWALDNIYIGQQCPNMCSGHGWCDHGVCRCDSGFRGTECQPENPLSSTIMSDFENPDTLKTEWQEIIGGEIVKPEEGCGVISSGSSLYFNKAGKRQLVSWDLDTIWVDFVQFYIQIGGETSSCNKPDSREEGVLLQYSNNGGINWQLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEGYDQWAIDDIIILSEKQKHIIPVVNPTLPQNFYEKPAFDYPMNQMSVWLMLANEGMTKNESFCSATPSAMLFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCTSQYSSSAPVLLQYSHDAGLFWSLVKEGCYPASPGTKGCEGSSRELSEPSVYHTGDFEDWTRVTIVIPRSLAASKTRFRWIQESSSHKSVPPFGLDGVYISEPCPNYCSGHGDCVSGVCFCDLGYTASHGTCVSNVPNHSEMFDRFERKLSPLWYKITGGQVGTGCGVLSDGKSLYFNGPGKREAKTVPLDTTNIRLVQFYVQLGSKSVGSSCNRPRARNEGLVVQYTNDNGITWSLLRELDFMSYLEPQVVSIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLIGMNDSSQTGFQDKFDGTVDLQASWYRIQGGQVDIDCLSMDTALMFSENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHSVHLQYSLNNGRDWHLVTEECVPPTIGCQQYTESSIYTSERFQNWKRVTVYLPPSTNSPRTRFRWIQYNYASGVDSWAIDNVVLATGCPWMCSGHGICDSGHCMCDRGFGGPYCVPVLPLPSVLKDDFNGNLHPDLWPEVYGAERGNLNGDTIKSGTALIFKGEGLRMLVSRDLDCTNTVYIQFSFKFIAKGTPERSHSILLQYSVNGGITWQLIDEFYFTQTTDVLFINVPLPYAAQSNATRFRLWQPYNNGKKEEIWIIDDFIIDGNNLKNPIILLDTFDFGPKEDNWFFYPGGNIGLYCPYSSKRAPEEDSAMVFVSNEVGEHSITTRDLSVNENTIIQFEINIGCTTDSSSADPVKLEFSRDLGATWHLLLPLCYSSSSHLSSLCSTEHHPSSTYYAGTTQVSSSCSFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCNGHGSCINGTKCICDPGYSGPTCKISTKNSDFLKDDFEGQLESDRFLLVSGGKPSRKCGIMSGGNNLFFNEEGLRMLMTRDLDLSQARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYIALEIPLKARSSSTRLRWWQPSENGHFYSPWVIDQILIGGNISGNTILEDDFTTLDSRKWLLHPGGTKMPVCGSAGDALVFIEKASTRYVVTTDIVVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLTWHPILKDCLPTNVECNKYHLQRILISDTFNKWTRVTLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCIDMCSGHGKCTQDNCVCDEHWGGLYCDEPETPLPTQLKDNFNRSPSNQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRMLVTVDLNLTSAEFIQFYFMYGCLITPNNRNQGVLLEYSVNGGITWSLLMEIFYDQFSKPGFVNILLPYDAKAIGTRFRWWQPKHDGLDQNDWAIDNVLISGSADQRTVMLDTFSSAPLPQHERAPADAGPTGRIAFDMAVEDKTTVNEHWLFHDDCSIERFCDSPDGVMICGSHDGREVYAVTHDLTPTEGWIMQFKVSVGCKPSEKVAQNQVHVQYSTDFGVSWSYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRVTYTLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCLENCRGHGDCLNEQCICDPGYSGPNCYLTQTLKTFLKERFDNEEIKPDLWMSLEGGNTCTECGILAEDTTLYFGGATVRQAVTQDLDLRGAKFLQYWGRIGSENNMTTCHRPTCRKEGVLLDYSIDGGISWTLLHEMDYQKYISVRHDYILLPEHALTNTTRLRWWQPFTLSSGIVVPGPERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNILSSRELIIQPGYMMQFKIVVGCEANSCGDLHSVMLEYTKDARTDSWQLVQTHCLPSSSNSIGCSPFQFHEATIYNSVNSSMWRRITIQLPDHVSSSATQFRWIQKGEELEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDEGFQGDDCSVFSHDLPSYIKDNFESERVTEINWETIQGGVIGNGCGQLAPYAHGDSLYFNGCQVRQAVTKPLDLTRASKIMFVLQIGSISQTDSCNTNLSDPNTVDKAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNVPLEARMKGVLLRWWQPRHSGTGHDQWALDHVEVVLTRKQNYMMNFSRQHGLRHFYNRRQRSLRRYP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YXD6H0YXD6_TAEGURELN3447
A0A674GV10A0A674GV10_TAEGURELN2911

Keywords

Genome annotation databases

Similar Proteins

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