A0A674C4T9 · A0A674C4T9_SALTR
- ProteinRAF proto-oncogene serine/threonine-protein kinase
- Generaf1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids546 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | Ras protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRAF proto-oncogene serine/threonine-protein kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Salmo
Accessions
- Primary accessionA0A674C4T9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MKGFPYQRRSSDDGKM | ||||||
Region | 1-21 | Disordered | ||||
Sequence: MKGFPYQRRSSDDGKMADPKT | ||||||
Domain | 23-96 | RBD | ||||
Sequence: STIRVYLPNKQCTVVNARPGMTLHNCLIKAMKVRGLQPECCAVFRLHSAQRKSRMDWNTDATSLIGEELLVDVL | ||||||
Domain | 103-149 | Phorbol-ester/DAG-type | ||||
Sequence: THNFVRNTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMC | ||||||
Domain | 253-513 | Protein kinase | ||||
Sequence: VVLQNRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTEDNLAIVTQWCDGSSLYHHLHIQETNLQMFQLMDIARQTAQGMNYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKARWSGSYQVEQPSGSILWMAPEVIRMQDNNPYSFQSDVYSYGVVLYELMTGELPYSMIATRDQIIFMVGRGSLFPELSKLYKNCPKAMKRLVADCIKKSKDDRPLFPQILSSIELL | ||||||
Domain | 439-507 | Cyclic nucleotide-binding | ||||
Sequence: GVVLYELMTGELPYSMIATRDQIIFMVGRGSLFPELSKLYKNCPKAMKRLVADCIKKSKDDRPLFPQIL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length546
- Mass (Da)61,869
- Last updated2020-06-17 v1
- Checksum1FA3327950633AEB
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A674C6H6 | A0A674C6H6_SALTR | raf1 | 664 | ||
A0A674C5V5 | A0A674C5V5_SALTR | raf1 | 614 | ||
A0A674C5V6 | A0A674C5V6_SALTR | raf1 | 320 | ||
A0A674C691 | A0A674C691_SALTR | raf1 | 596 | ||
A0A674C4U0 | A0A674C4U0_SALTR | raf1 | 647 | ||
A0A674C4V5 | A0A674C4V5_SALTR | raf1 | 640 | ||
A0A674C5P9 | A0A674C5P9_SALTR | raf1 | 637 | ||
A0A674C5J4 | A0A674C5J4_SALTR | raf1 | 608 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MKGFPYQRRSSDDGKM |
Keywords
- Technical term