A0A671XPE8 · A0A671XPE8_SPAAU

  • Protein
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • Gene
    PPIP5K1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiondiphosphoinositol-pentakisphosphate kinase activity
Molecular Functioninositol heptakisphosphate kinase activity
Molecular Functioninositol hexakisphosphate 1-kinase activity
Molecular Functioninositol hexakisphosphate 3-kinase activity
Molecular Functioninositol hexakisphosphate 5-kinase activity
Molecular Functioninositol-1,3,4,5,6-pentakisphosphate kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • EC number

Gene names

    • Name
      PPIP5K1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus

Accessions

  • Primary accession
    A0A671XPE8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_502533819721-1107Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain36-125VIP1 N-terminal
Region900-924Disordered
Compositional bias910-924Polar residues

Sequence similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,107
  • Mass (Da)
    125,393
  • Last updated
    2020-06-17 v1
  • Checksum
    9A51F3653A456535
MSSVVITLVSLVISLHLSLLYPGLLCPLHKPPERQIVVGICAMMKKSKSKPMTQILERLCKFDYINVVIFPEEVILEEPVEKWPLCDCLISFHSKGFPLDKAVEYAKLRNPLLINDLNMQYYIQDRREVYRILREEGIDLPRYAVLNRDPDNPEECNLVEGEDHVEVNGEVFPKPFVEKPVCAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTSMEKLVARKVCLAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKVLGNMVMRELAPQFHIPWSIPMEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVRHPLFFELFDKYGGYKSGKLKLKKPKQLQEVLDIARLLLVELGQHTDCEIEEKKSKLEQLKTVLEMYGHFSGINRKVQLTYLRNGQPKASSEEEDSKKDGPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLTDCQQKVKARLHEIMQKDQELTQDDYQKLAPTGSPSLVNSMKVIENPVKTCDKVYGLIQSLTSQIRKRLEDPKSADLQLYHSETLELMLQRWSKLERDFRTKNGRYDISKIPDIYDCIKYDSQHNASLGLEDTLELFRLSRALADIVIPQEYGISKAEKLDIAQAYCVPLMKKIQLDLQRTHEDEAVNKLHPLYSRGVMSPGRHVRTRLYFTSESHVHSLLSIFRYGGLLDEEKDWQWKQAMDYLSAVSELNYMTQIVIMLYEDNDKVSLQRERFHVELHFSPGVKGCEDEENVPLGYGFRPASSENQDKKPNQGSLEDLSQDQVDQALPVSEPINIQRRSPMIRNRKTGSMEVPDLSVSGADVIGTTGCVSVSPVCAAGFEGCSMVPSIYPLETLHNSLSLKQVDEFLNNVCESSSEAHAKTMKGRPADESAPYVNKKHWAAIKATRTFLPSPNIILHYHQEHHSYLDDFPQQPLSSSGSETSLRPPSQPLWRECLQDFMAE

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A671XNQ5A0A671XNQ5_SPAAUPPIP5K11180
A0A671XRA8A0A671XRA8_SPAAUPPIP5K11105
A0A671XPE5A0A671XPE5_SPAAUPPIP5K11175
A0A671XPH9A0A671XPH9_SPAAUPPIP5K11129
A0A671XQ36A0A671XQ36_SPAAUPPIP5K11121
A0A671XP48A0A671XP48_SPAAUPPIP5K11129
A0A671XP25A0A671XP25_SPAAUPPIP5K11175
A0A671XNT6A0A671XNT6_SPAAUPPIP5K11153
A0A671XVB9A0A671XVB9_SPAAUPPIP5K11147

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias910-924Polar residues

Keywords

Genome annotation databases

Similar Proteins

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