A0A671XPE8 · A0A671XPE8_SPAAU
- ProteinInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- GenePPIP5K1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1107 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADPThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | diphosphoinositol-pentakisphosphate kinase activity | |
Molecular Function | inositol heptakisphosphate kinase activity | |
Molecular Function | inositol hexakisphosphate 1-kinase activity | |
Molecular Function | inositol hexakisphosphate 3-kinase activity | |
Molecular Function | inositol hexakisphosphate 5-kinase activity | |
Molecular Function | inositol-1,3,4,5,6-pentakisphosphate kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus
Accessions
- Primary accessionA0A671XPE8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MSSVVITLVSLVISLHLSLL | ||||||
Chain | PRO_5025338197 | 21-1107 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase | |||
Sequence: YPGLLCPLHKPPERQIVVGICAMMKKSKSKPMTQILERLCKFDYINVVIFPEEVILEEPVEKWPLCDCLISFHSKGFPLDKAVEYAKLRNPLLINDLNMQYYIQDRREVYRILREEGIDLPRYAVLNRDPDNPEECNLVEGEDHVEVNGEVFPKPFVEKPVCAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTSMEKLVARKVCLAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKVLGNMVMRELAPQFHIPWSIPMEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVRHPLFFELFDKYGGYKSGKLKLKKPKQLQEVLDIARLLLVELGQHTDCEIEEKKSKLEQLKTVLEMYGHFSGINRKVQLTYLRNGQPKASSEEEDSKKDGPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLTDCQQKVKARLHEIMQKDQELTQDDYQKLAPTGSPSLVNSMKVIENPVKTCDKVYGLIQSLTSQIRKRLEDPKSADLQLYHSETLELMLQRWSKLERDFRTKNGRYDISKIPDIYDCIKYDSQHNASLGLEDTLELFRLSRALADIVIPQEYGISKAEKLDIAQAYCVPLMKKIQLDLQRTHEDEAVNKLHPLYSRGVMSPGRHVRTRLYFTSESHVHSLLSIFRYGGLLDEEKDWQWKQAMDYLSAVSELNYMTQIVIMLYEDNDKVSLQRERFHVELHFSPGVKGCEDEENVPLGYGFRPASSENQDKKPNQGSLEDLSQDQVDQALPVSEPINIQRRSPMIRNRKTGSMEVPDLSVSGADVIGTTGCVSVSPVCAAGFEGCSMVPSIYPLETLHNSLSLKQVDEFLNNVCESSSEAHAKTMKGRPADESAPYVNKKHWAAIKATRTFLPSPNIILHYHQEHHSYLDDFPQQPLSSSGSETSLRPPSQPLWRECLQDFMAE |
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-125 | VIP1 N-terminal | ||||
Sequence: IVVGICAMMKKSKSKPMTQILERLCKFDYINVVIFPEEVILEEPVEKWPLCDCLISFHSKGFPLDKAVEYAKLRNPLLINDLNMQYYIQD | ||||||
Region | 900-924 | Disordered | ||||
Sequence: LGYGFRPASSENQDKKPNQGSLEDL | ||||||
Compositional bias | 910-924 | Polar residues | ||||
Sequence: ENQDKKPNQGSLEDL |
Sequence similarities
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,107
- Mass (Da)125,393
- Last updated2020-06-17 v1
- Checksum9A51F3653A456535
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A671XNQ5 | A0A671XNQ5_SPAAU | PPIP5K1 | 1180 | ||
A0A671XRA8 | A0A671XRA8_SPAAU | PPIP5K1 | 1105 | ||
A0A671XPE5 | A0A671XPE5_SPAAU | PPIP5K1 | 1175 | ||
A0A671XPH9 | A0A671XPH9_SPAAU | PPIP5K1 | 1129 | ||
A0A671XQ36 | A0A671XQ36_SPAAU | PPIP5K1 | 1121 | ||
A0A671XP48 | A0A671XP48_SPAAU | PPIP5K1 | 1129 | ||
A0A671XP25 | A0A671XP25_SPAAU | PPIP5K1 | 1175 | ||
A0A671XNT6 | A0A671XNT6_SPAAU | PPIP5K1 | 1153 | ||
A0A671XVB9 | A0A671XVB9_SPAAU | PPIP5K1 | 1147 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 910-924 | Polar residues | ||||
Sequence: ENQDKKPNQGSLEDL |
Keywords
- Technical term