A0A671WG31 · A0A671WG31_SPAAU
- ProteinBroad substrate specificity ATP-binding cassette transporter ABCG2
- GeneLOC115588406
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids650 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- indoxyl sulfate(in) + ATP + H2O = indoxyl sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- riboflavin(in) + ATP + H2O = riboflavin(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- estrone 3-sulfate(in) + ATP + H2O = estrone 3-sulfate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | riboflavin transmembrane transporter activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBroad substrate specificity ATP-binding cassette transporter ABCG2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus
Accessions
- Primary accessionA0A671WG31
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 382-402 | Helical | |||
Transmembrane | 464-482 | Helical | |||
Transmembrane | 488-506 | Helical | |||
Transmembrane | 518-541 | Helical | |||
Transmembrane | 625-643 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5025543058 | 23-650 | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ||
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 45-283 | ABC transporter | |||
Sequence similarities
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length650
- Mass (Da)72,404
- Last updated2020-06-17 v1
- Checksum715F3846D577BDD8
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A671WJ08 | A0A671WJ08_SPAAU | LOC115588406 | 667 | ||
A0A671WK79 | A0A671WK79_SPAAU | LOC115588406 | 660 | ||
A0A671WJS3 | A0A671WJS3_SPAAU | LOC115588406 | 652 | ||
A0A671WG21 | A0A671WG21_SPAAU | LOC115588406 | 654 | ||
A0A671WFX0 | A0A671WFX0_SPAAU | LOC115588406 | 658 | ||
A0A671WF81 | A0A671WF81_SPAAU | LOC115588406 | 639 | ||
A0A671WDE1 | A0A671WDE1_SPAAU | LOC115588406 | 654 | ||
A0A671WC71 | A0A671WC71_SPAAU | LOC115588406 | 654 | ||
A0A671WBZ3 | A0A671WBZ3_SPAAU | LOC115588406 | 657 |
Keywords
- Technical term