A0A671WG31 · A0A671WG31_SPAAU

  • Protein
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • Gene
    LOC115588406
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

  • 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • indoxyl sulfate(in) + ATP + H2O = indoxyl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • riboflavin(in) + ATP + H2O = riboflavin(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)
  • dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • estrone 3-sulfate(in) + ATP + H2O = estrone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionefflux transmembrane transporter activity
Molecular Functionriboflavin transmembrane transporter activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family G member 2
    • Urate exporter

Gene names

    • Name
      LOC115588406

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus

Accessions

  • Primary accession
    A0A671WG31

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane382-402Helical
Transmembrane464-482Helical
Transmembrane488-506Helical
Transmembrane518-541Helical
Transmembrane625-643Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_502554305823-650Broad substrate specificity ATP-binding cassette transporter ABCG2

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain45-283ABC transporter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    650
  • Mass (Da)
    72,404
  • Last updated
    2020-06-17 v1
  • Checksum
    715F3846D577BDD8
LTHPLTFAVRHIASALFPVTAAVDQNKKPCGSTVSFHNIQYKVQLKSGFLCKRKTSPREILVDLNGIMRPGLNAILGPTGSGKSSFLDILAARKDPSGLSGEVLIDRAPQPPNFKCLSGYVVQEDVVMGTLTVRENLRFSAALRLPCSVPQSEKEARVNHLIKELGLTKVADSKVGTQMTRGISGGERKRTNIGMELIIDPSVLFLDEPTTGLDASTANSVLLLLKRMAGHGRTIILSIHQPRYSIYRLFDTLTLLVNGKMVYHGPAPNALDYFANIGYPCEPHNNPADFFLDVINGDFTATTMTKMHGCEDLHGEGIIGEYRNSSYSSDTRAELDRIVQEKECILCPKSRTITYNSSFFHQLRWVLKRTFQNLMLNPQTSVAQLGVNIFLALIVGAIFYGVKDDQSGIQNRMGALFFITTNQCFSTVSAAELFIIERKLFVHEYISGYYRVSVYFLSKILSDITLRTITSVIFSCIVYFMIGLKSTAAAFFLFTLTVTLVAYTATAMTMAISADQSVVALANIFMTITFVFMMIFSGLLVNLPSIMDWLAWLKYFSIPRYGLAALKINEFVGLKFCEEAVIRNTNMSASMTNCSVSTVGLTCTGEQYLDYLGIEYTTWGLWENHVALTIMTFMFLIIAYLKLRFIRKFT

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A671WJ08A0A671WJ08_SPAAULOC115588406667
A0A671WK79A0A671WK79_SPAAULOC115588406660
A0A671WJS3A0A671WJS3_SPAAULOC115588406652
A0A671WG21A0A671WG21_SPAAULOC115588406654
A0A671WFX0A0A671WFX0_SPAAULOC115588406658
A0A671WF81A0A671WF81_SPAAULOC115588406639
A0A671WDE1A0A671WDE1_SPAAULOC115588406654
A0A671WC71A0A671WC71_SPAAULOC115588406654
A0A671WBZ3A0A671WBZ3_SPAAULOC115588406657

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help