A0A671L9P6 · A0A671L9P6_9TELE

  • Protein
    Elongation of very long chain fatty acids protein 5
  • Gene
    LOC107664697
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid.
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Catalytic activity

  • (11Z)-octadecenoyl-CoA + malonyl-CoA + H+ = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + malonyl-CoA + H+ = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H+ = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (9Z)-hexadecenoyl-CoA + malonyl-CoA + H+ = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (9Z)-octadecenoyl-CoA + malonyl-CoA + H+ = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H+ = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H+ = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • a very-long-chain acyl-CoA + malonyl-CoA + H+ = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
    EC:2.3.1.199 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; polyunsaturated fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentdendrite
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfatty acid elongase activity
Biological Processfatty acid elongation, monounsaturated fatty acid
Biological Processfatty acid elongation, polyunsaturated fatty acid
Biological Processfatty acid elongation, saturated fatty acid
Biological Processlong-chain fatty-acyl-CoA biosynthetic process
Biological Processsphingolipid biosynthetic process
Biological Processunsaturated fatty acid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation of very long chain fatty acids protein 5
  • EC number
  • Alternative names
    • 3-keto acyl-CoA synthase ELOVL5
    • ELOVL fatty acid elongase 5
      (ELOVL FA elongase 5
      )
    • Very long chain 3-ketoacyl-CoA synthase 5
    • Very long chain 3-oxoacyl-CoA synthase 5

Gene names

    • Name
      LOC107664697
    • Synonyms
      ELOVL5

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Sinocyclocheilus

Accessions

  • Primary accession
    A0A671L9P6

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Cell projection, dendrite
Membrane
; Multi-pass membrane protein
Note: In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane38-55Helical
Transmembrane67-87Helical
Transmembrane120-138Helical
Transmembrane150-167Helical
Transmembrane173-192Helical
Transmembrane213-230Helical
Transmembrane236-257Helical

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region271-297Disordered
Compositional bias272-286Polar residues

Sequence similarities

Belongs to the ELO family. ELOVL5 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    297
  • Mass (Da)
    35,520
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    4ED8AEC9F695CFC34F4B7641ACA05F5C
MPYRLKMETFNHRVNTYIDSWMGPRDPRVRGWLLLDNYIPTFAFTVMYLLIVWMGPKYMKNRQPYSCRALLVPYNLGLTLLSFYMFYELVMSVYQGGYNFFCQNTHSGGEADNRMINVLWWYYFSKLIEFMDTFFFILRKNNHQISFLHVYHHATMLNIWWFVMNWVPCGHSYFGATFNSFIHVLMYSYYGLSAVPAMRPYLWWKKYITQGQLVQFVLTMFQTSCAVVWPCGFPMGWLYFQITYMITLILLFSNFYIKTYKSCMGSRKTDHSNGSINGHTNGVTSNEKVKYRKPRTD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias272-286Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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