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A0A671EDB3 · A0A671EDB3_RHIFE

Function

function

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site247-255ATP (UniProtKB | ChEBI)
Binding site274ATP (UniProtKB | ChEBI)
Active site376Proton acceptor

GO annotations

AspectTerm
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular Functionactivin binding
Molecular Functionactivin receptor activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionSMAD binding
Molecular Functiontransforming growth factor beta binding
Molecular Functiontransforming growth factor beta receptor activity, type II
Molecular Functiontype I transforming growth factor beta receptor binding
Biological Processapoptotic process
Biological Processcell differentiation
Biological Processheart development
Biological Processprotein phosphorylation
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TGF-beta receptor type-2
  • EC number
  • Short names
    TGFR-2
  • Alternative names
    • TGF-beta type II receptor
    • Transforming growth factor-beta receptor type II

Gene names

    • Name
      TGFBR2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Rhinolophoidea > Rhinolophidae > Rhinolophinae > Rhinolophus

Accessions

  • Primary accession
    A0A671EDB3

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane raft
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane157-186Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-23
ChainPRO_502537742624-564TGF-beta receptor type-2
Disulfide bond51↔84
Disulfide bond54↔71
Disulfide bond61↔67
Disulfide bond77↔101
Disulfide bond119↔133
Disulfide bond135↔140

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain241-541Protein kinase

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    564
  • Mass (Da)
    64,171
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    5687EB0A6F5C18E216465DB84C919284
MGWGLLRGLWPLHIVLWTHIASTIPPHVQKSVNNNMMVTDNNGAVKLPKLCKFCDVRSSTCDNQKSCVSNCSITSICENPHEVCVAVWRKNDENITLETVCHDPKLVYHVLEDAASTKCIMKEKKWGKTFFMCSCSTDECNDVIIFSEEYSTNNPDLLLVIFQVTGISLLPPLGIAIAVIITFYCYRVHRKQKLTPSWETSKQRKLIEFSEQLAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKMEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTLCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLSTTK

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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