A0A671DYV8 · A0A671DYV8_RHIFE

Function

Catalytic activity

  • 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • indoxyl sulfate(in) + ATP + H2O = indoxyl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • riboflavin(in) + ATP + H2O = riboflavin(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)
  • dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • estrone 3-sulfate(in) + ATP + H2O = estrone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Molecular FunctionABC-type xenobiotic transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionefflux transmembrane transporter activity
Molecular Functionriboflavin transmembrane transporter activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family G member 2
    • Urate exporter

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Rhinolophoidea > Rhinolophidae > Rhinolophinae > Rhinolophus

Accessions

  • Primary accession
    A0A671DYV8

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane396-416Helical
Transmembrane483-499Helical
Transmembrane505-527Helical
Transmembrane539-565Helical
Transmembrane631-650Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-286ABC transporter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    655
  • Mass (Da)
    72,591
  • Last updated
    2020-06-17 v1
  • Checksum
    A4092115C114131A
MSSSNDQVFIPVSQRNTNGLTGMPSNDPKSFTKGAVLSFHNIYYKVKVKSGFLLGRKILEKEILTNINGIMRPGLNAILGPTGGGKSSLLDVLAARKDPQGLSGDVLINGAPRPANFKCTSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMTNHEKNERINKVIQELGLAKVADSKVGTQFTRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRVMFHGPAQEALGYFASAGHHCESYNNPADFFLDVINGDSSAVISNREDEGGEAKETEEPSKREKPLIEKLAEFYVNSAFFRDTKAELDQFSGVQKKKSVVFKELTYATSFCHQLKWIAKRSFKNLLGNPQASIAEIIVTIFLGLIIGAIFYDLKHDPTGIQNRAGVLFFLTTNQCFSSISAVELFVVEKKLFTHEYISGYYRVSSYFFGKLLSDLLPMRMLPSIIFTCITYFLLGLKPVVESFFIMMFTLMMVAFTASSMALAIAAGQSVVSVATLLMTITFVFMMIFSGLLVNLTTIVPWLSWLQYFSIPRYGYTALRHNEFLGQNFCPGLNVTANNTCSFAICTGEEYLIIQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKFS

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A671DYU8A0A671DYU8_RHIFE655
A0A671DZP7A0A671DZP7_RHIFE655
A0A671E727A0A671E727_RHIFE655
A0A671E6W7A0A671E6W7_RHIFE655
A0A671E3P4A0A671E3P4_RHIFE655

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help