A0A668UH26 · A0A668UH26_OREAU
- ProteinDihydropyrimidine dehydrogenase [NADP(+)]
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids623 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 5,6-dihydrothymine + NADP+ = thymine + NADPH + H+This reaction proceeds in the backward direction.
Cofactor
Protein has several cofactor binding sites:
Pathway
Amino-acid biosynthesis; beta-alanine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | uracil binding | |
Biological Process | beta-alanine biosynthetic process | |
Biological Process | thymine catabolic process | |
Biological Process | uracil catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropyrimidine dehydrogenase [NADP(+)]
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Oreochromini > Oreochromis
Accessions
- Primary accessionA0A668UH26
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-38 | Dihydroprymidine dehydrogenase | |||
Domain | 78-238 | FAD/NAD(P)-binding | |||
Domain | 277-582 | Dihydroorotate dehydrogenase catalytic | |||
Sequence similarities
Belongs to the dihydropyrimidine dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length623
- Mass (Da)67,430
- Last updated2020-06-17 v1
- Checksum8CDD264FA0608F8E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A668UGV5 | A0A668UGV5_OREAU | 657 |
Keywords
- Technical term