A0A665V3N7 · A0A665V3N7_ECHNA
- ProteinDelta(14)-sterol reductase LBR
- Genelbr
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids551 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H+ = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + NADPH + H+ = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nuclear inner membrane | |
Molecular Function | delta14-sterol reductase activity | |
Molecular Function | DNA binding | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase LBR
- EC number
- Short namesC14SR ; Delta-14-SR
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Carangaria > Carangiformes > Echeneidae > Echeneis
Accessions
- Primary accessionA0A665V3N7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Nucleus inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 140-167 | Helical | |||
Transmembrane | 187-210 | Helical | |||
Transmembrane | 231-249 | Helical | |||
Transmembrane | 261-281 | Helical | |||
Transmembrane | 388-412 | Helical | |||
Transmembrane | 418-437 | Helical | |||
Transmembrane | 458-479 | Helical | |||
Transmembrane | 491-517 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-62 | Tudor | |||
Region | 58-95 | Disordered | |||
Compositional bias | 68-86 | Basic residues | |||
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length551
- Mass (Da)62,754
- Last updated2020-06-17 v1
- MD5 Checksum2B3F2EE9159334A84E8ED7F2C5AEF56E
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A665V2I3 | A0A665V2I3_ECHNA | lbr | 617 | ||
A0A665V2R2 | A0A665V2R2_ECHNA | lbr | 593 | ||
A0A665V2L2 | A0A665V2L2_ECHNA | lbr | 494 | ||
A0A665V3P2 | A0A665V3P2_ECHNA | lbr | 534 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 68-86 | Basic residues | |||
Keywords
- Technical term