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A0A665V3N7 · A0A665V3N7_ECHNA

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear inner membrane
Molecular Functiondelta14-sterol reductase activity
Molecular FunctionDNA binding
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase LBR
  • EC number
  • Short names
    C14SR
    ; Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Integral nuclear envelope inner membrane protein
    • Lamin-B receptor
    • Sterol C14-reductase

Gene names

    • Name
      lbr

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Carangaria > Carangiformes > Echeneidae > Echeneis

Accessions

  • Primary accession
    A0A665V3N7

Proteomes

Subcellular Location

Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Nucleus inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane140-167Helical
Transmembrane187-210Helical
Transmembrane231-249Helical
Transmembrane261-281Helical
Transmembrane388-412Helical
Transmembrane418-437Helical
Transmembrane458-479Helical
Transmembrane491-517Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain4-62Tudor
Region58-95Disordered
Compositional bias68-86Basic residues

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    551
  • Mass (Da)
    62,754
  • Last updated
    2020-06-17 v1
  • MD5 Checksum
    2B3F2EE9159334A84E8ED7F2C5AEF56E
MPAVKYQKGEKVMGRWPGSNLYYEVKVLSFDSMSQLYTVIYKDGTELELKEQDIKSAAGFQARSRSRSRSRSPGRRRSRSRSPARTTRRSSSRTAAAVAAAAITDSVPSSRRETRLKDTLEVRPSPLVISTSHSYKLKPLLMCIFLLAGAYFWLLFLPAWVLFLIIQVNLEDPSLANFPPPLPPLEAFLDAQALAFVILWIAFQAMLYILPVGKLSEGMPLMSGERLKYRTNGFFAIVVSAVVVAVALHQGLDLTYIHSHFLQLAVATFLIATLLSVYLYVRSRYAPQEQLALGGNSGNVVYDFFKGHELNPRIKDFDLKFFCEMRPGLIGWCLINFAMALAEMKQQNLEAPSNSMILVNLFQLLYVVDGLWNEEAILTTMDLMHDGFGFMLAFGDLVWVPFTYTMQAYYLVRHPNPLSFPALTAIVILKLVGFYIFRKSNSEKNAFRRNPSDPKLSYLKTIPTATGKSLLVSGWWGVIRHPNYLGDLLMALAWSLPCGFSHLLPWYYMIYFIILLVHRDSRDMSECRRKYGSAWDEYCRTVRYRIIPCVY

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A665V2I3A0A665V2I3_ECHNAlbr617
A0A665V2R2A0A665V2R2_ECHNAlbr593
A0A665V2L2A0A665V2L2_ECHNAlbr494
A0A665V3P2A0A665V3P2_ECHNAlbr534

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias68-86Basic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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