Mediator subunit MED25 physically recruits LUH to MYC2 target promoters that then links MYC2 with HAC1-dependent acetylation of Lys-9 of histone H3 (H3K9ac) to activate JAZ2 and LOX2 Moreover LUH promotes hormone-dependent enhancement of protein interactions between MYC2 and its coactivators MED25 and HAC1.
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