A0A653BJV4 · A0A653BJV4_CALMS
- ProteinDihydropyrimidine dehydrogenase [NADP(+)]
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1046 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
Catalytic activity
- 5,6-dihydrouracil + NADP+ = H+ + NADPH + uracil
Cofactor
Protein has several cofactor binding sites:
Note: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
Pathway
Amino-acid biosynthesis; beta-alanine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | beta-alanine biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropyrimidine dehydrogenase [NADP(+)]
- EC number
- Short namesDHPDHase ; DPD
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Chrysomeloidea > Chrysomelidae > Bruchinae > Bruchini > Callosobruchus
Accessions
- Primary accessionA0A653BJV4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 961-993 | 4Fe-4S ferredoxin-type | ||||
Sequence: VVALIDDDMCINCGKCYMTCNDSGYQAIRFDKE | ||||||
Domain | 995-1024 | 4Fe-4S ferredoxin-type | ||||
Sequence: HIPKVTDDCTGCTLCLSVCPIIDCITMVPK |
Sequence similarities
Belongs to the dihydropyrimidine dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,046
- Mass (Da)114,288
- Last updated2020-04-22 v1
- ChecksumA9DD296EED469FA7
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A653BJD2 | A0A653BJD2_CALMS | CALMAC_LOCUS1514 | 1062 | ||
A0A653BL11 | A0A653BL11_CALMS | CALMAC_LOCUS1514 | 576 | ||
A0A653BJB0 | A0A653BJB0_CALMS | CALMAC_LOCUS1514 | 897 | ||
A0A653BJE3 | A0A653BJE3_CALMS | CALMAC_LOCUS1514 | 1023 | ||
A0A653BJ87 | A0A653BJ87_CALMS | CALMAC_LOCUS1514 | 470 | ||
A0A653BK43 | A0A653BK43_CALMS | CALMAC_LOCUS1514 | 702 | ||
A0A653BJK2 | A0A653BJK2_CALMS | CALMAC_LOCUS1514 | 791 |
Keywords
- Technical term