A0A653BJB0 · A0A653BJB0_CALMS

Function

function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

FMN (UniProtKB | Rhea| CHEBI:58210 )

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.

Pathway

Amino-acid biosynthesis; beta-alanine biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functiondihydropyrimidine dehydrogenase (NADP+) activity
Molecular Functionnucleotide binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processbeta-alanine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropyrimidine dehydrogenase [NADP(+)]
  • EC number
  • Short names
    DHPDHase
    ; DPD
  • Alternative names
    • Dihydrothymine dehydrogenase
    • Dihydrouracil dehydrogenase

Gene names

    • ORF names
      CALMAC_LOCUS1514

Organism names

Accessions

  • Primary accession
    A0A653BJB0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain835-8674Fe-4S ferredoxin-type
Domain869-8974Fe-4S ferredoxin-type

Sequence similarities

Belongs to the dihydropyrimidine dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    897
  • Mass (Da)
    97,865
  • Last updated
    2020-04-22 v1
  • Checksum
    17B6679C9A17DDAF
MVCPTSDLCVGGCNLQASEEGPINIGGLQQFATEVFSRMGVKQTRDPRTPRPKNPNAKIALLGAGPASLSCATFLGRLGYDDITIYEKEDVLGGLSTTEIPQYRLPMTVINFEIQLVKDLGVKIETGRRLSTKDLTIESLLKKSDAVFLGIGLPQPKISPVFKGLTEQMGFYTSKSFLPRVARASKNMENSRCPCKAKADQMPKLRGNVIVLGAGDTAFDCATSALRCGARKVFVVFRRGFSNIRAVPEEVSAAVEEKCELIGFLSPHSVNVKDGKIVSVTFSRTEQTEDGQWVQDVEQLNTLKCNYLISAFGSGLEDQDMIEALKPLKLTSNNLPEVDVTTMQSSHPKVWCGGDVAGVAETTVESVNDGKIAAWYIHCALEGLPRSTKPKLPLFHTDIDEVDISVEVCGVKFENPFGLASAPPVTTTAMIRRAFEQGWGFVVTKTFCLDKDEVTNVSPRIIRGTTSGYTYGPQQGSFLNIEVISEKCMDYWLTGIRELKKDFPSKIIIASIMCAFVEEDWKLLAKKAEECGSDMLELNLSCPHGMGESGMGLACGQKPELVRQISKWVRETIKIPFFIKLTPNITDIRDIAQAAKEGGAWGGAAINTVSGLMYVKPDASAWPAVGIDKRTTYGGVSGNATRPMGLKAVSAIANKVPDFAILGIGGIESAETAFQYLQCGASAVQVCSAVQNQDFTLIDDYCTGLKALLYLDGKYPGWEGQSPPTFKHQKGKPVIPLYDATGKKLPHFGKYQRQREEQLADLYRECKIDDKVFLHHNGKQNGYCEELSNGFNGVTNGICNGSAVTKPQVPRVKDIIGRALPRIGAYKQLNNRQQVVALIDDDMCINCGKCYMTCNDSGYQAIRFDKETHIPKVTDDCTGCTLCLSVCPIIDCITICA

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A653BJD2A0A653BJD2_CALMSCALMAC_LOCUS15141062
A0A653BL11A0A653BL11_CALMSCALMAC_LOCUS1514576
A0A653BJE3A0A653BJE3_CALMSCALMAC_LOCUS15141023
A0A653BJ87A0A653BJ87_CALMSCALMAC_LOCUS1514470
A0A653BK43A0A653BK43_CALMSCALMAC_LOCUS1514702
A0A653BJK2A0A653BJK2_CALMSCALMAC_LOCUS1514791
A0A653BJV4A0A653BJV4_CALMSCALMAC_LOCUS15141046

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAACVG010001765
EMBL· GenBank· DDBJ
VEN35663.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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