A0A650FYA6 · A0A650FYA6_9HIV2

Function

Catalytic activity

  • 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
    EC:3.1.13.2 (UniProtKB | ENZYME | Rhea)
  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding.

1949100200300400500600700800900
TypeIDPosition(s)Description
DNA binding879-926Integrase-type

GO annotations

AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular Functionexoribonuclease H activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological ProcessDNA recombination
Biological Processestablishment of integrated proviral latency
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processviral genome integration into host DNA

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Pol protein

Gene names

    • Name
      pol

Organism names

Accessions

  • Primary accession
    A0A650FYA6

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-87Peptidase A2
Domain141-331Reverse transcriptase
Domain659-700Integrase-type
Domain709-860Integrase catalytic
Domain879-926Integrase-type

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    949
  • Mass (Da)
    107,671
  • Last updated
    2020-04-22 v1
  • Checksum
    BF2BC56449238A3B
FSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGSNYSPKIVGGIGGFMNTKEYKNVEIEVLGKRIRATIMTGDTPFNILGRNVMTALGMSLNFPXAKIEPMKVMLKPGKDGPKLRQWPLTKEKIEALKEICEKMEKEGQLEEASPTNPYNTPTFAIRKKDKNKWRMLIDFRELNKVTQDFTEIQLGIPHPAGLAKRRRITVIDVGDAYFSIPLHEDFRQYTAFTLPSVNNAEPGKRYIYKVLPMGWKGSPAIFQHTMRQVLEPFRKANQDVTIIQYVDDILIASDRTDLEHDXVVLQLKELLNGIGFSTPXEKFQKDPPYQWMGYELWPTKWKLQKIQLPQKEVWTVNDIQKLVGVLNWAAQIYPGIKTKHLCRLIRGKMTLTEEVQWTELAEAELEENXIILXQEQEGHYYQEEKELEATVQKDQDNQWTYKIHQGEKILKVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFLEKIEPAQEEHEKFHSNIKELSHKFGLPKLVARQIVNSCXQCQQKGEAIHGQVNAELGTWQMDCTHLEGKVIIVAVHVASGFIEAEVIPQEXGRQTALFLLKLASRWPITHLHTDNGANFTSQDVKMVAWWVGIEQSFGVPYNPQSQGVVEAMNHHLKNQISRIRDQANTVETVVLMAVHCMNFKRRGGIGDMTPAERLINMITTEQEIQFSQAKNLKFKNFRVYFREGRDQLWKGPGELLWKGEGAVIVKVGTDIKVIPRRKAKIIKDYGGGKELDSGSHLEGAREDGEVA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue949

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN645969
EMBL· GenBank· DDBJ
QGV16538.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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