A0A650FVL1 · A0A650FVL1_HV1

Function

Catalytic activity

  • 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
    EC:3.1.13.2 (UniProtKB | ENZYME | Rhea)
  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding.

110001002003004005006007008009001,000
TypeIDPosition(s)Description
DNA binding935-982Integrase-type

GO annotations

AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular FunctionDNA binding
Molecular Functionexoribonuclease H activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological ProcessDNA recombination
Biological Processestablishment of integrated proviral latency
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processviral genome integration into host DNA

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Pol protein

Gene names

    • Name
      pol

Organism names

Accessions

  • Primary accession
    A0A650FVL1

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias13-31Polar residues
Region13-46Disordered
Domain73-142Peptidase A2
Domain196-386Reverse transcriptase
Domain586-709RNase H type-1
Domain715-756Integrase-type
Domain766-916Integrase catalytic
Domain935-982Integrase-type

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,000
  • Mass (Da)
    113,481
  • Last updated
    2020-04-22 v1
  • MD5 Checksum
    A183BDC83DBFDDDD9E1968B22871C15B
FFREAVAFQQRKAGKFSSEQTRTNSPSSRGLGEEGRDTEAGAERQGTASSLNFPQITLWQRPLVTVKIEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYDQILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNFPISPIETVPVSLKPGMDGPRVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEMDIYQYMDDLYVGSDLEIGQHRIKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDRWTVQPINLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIIPLTEEAELELAENREILKTPVHGVYYDPSKDLVAEVQKQGQDQWTYQIYQEPFKNLKTGKYARKRSAHTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQRETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLXKDPIIGAETFYVDGAASRETKLGKAGYVTDRGRQKVVSLTETTNQKTELHAIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESEVVNQIIEELIKKEKVYLSWVPAHKGIGGNEQVDKLVSSGIRKVLFLDGIDKAQEEHERYHSNWRTMASDFNLPPIVAKEIVANCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSNFTSAAVKAACWWANVRQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCMAGRQDED

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias13-31Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK867616
EMBL· GenBank· DDBJ
QGV15416.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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