A0A650FU62 · A0A650FU62_HV1

Function

Catalytic activity

  • 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
    EC:3.1.13.2 (UniProtKB | ENZYME | Rhea)
  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding.

110021002003004005006007008009001,000
TypeIDPosition(s)Description
DNA binding937-984Integrase-type

GO annotations

AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular FunctionDNA binding
Molecular Functionexoribonuclease H activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological ProcessDNA recombination
Biological Processestablishment of integrated proviral latency
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processviral genome integration into host DNA

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Pol protein

Gene names

    • Name
      pol

Organism names

Accessions

  • Primary accession
    A0A650FU62

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-48Disordered
Compositional bias14-39Polar residues
Domain75-144Peptidase A2
Domain198-388Reverse transcriptase
Domain588-711RNase H type-1
Domain717-758Integrase-type
Domain768-918Integrase catalytic
Domain937-984Integrase-type

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,002
  • Mass (Da)
    113,933
  • Last updated
    2020-04-22 v1
  • Checksum
    392D8C1B76FC7741
FFRETLAFPQGKAREFSSEQTRANSPTRRELQVWGRDNNSLSEAGADKGPASFNLPQITLWQRPLVRIKIGGQIKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQVPIEIYGHQAIGTVLIGPTPVNIIGRNLLTQIGCTLNFPISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPIFAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRRKNPEIIIYQYMDDLYVGSDLEIGQHRTKVEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDRWTVQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIRIRQLCKLLRGAKALTDIVPLTEEAELELAENREILKTPVHGVYYDPSKDLVAEVQKQGQDQWTYQIYQEPFKNLKTGKYAKRRSAHTNDVRQLVDVVQKIATESIVIWGKTPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTPPLVKLWYHLEKDPIEGAETFYVDGAASRETKLGKAGYVTNRGRQKVVSLTETTNQKTELHAIYLALQDSGSEVNIVTDSQYALGILQAQPDRSESEIVNQIIEELIKKEKVYLSWVPAHKGIGGNEQVDKLVSSGIRKVLFLDGIDKAQEEHERYHSNWRTMASDFNLPPIVAKEIVANCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVRVIHTDNGSNFTSAAVKAACWWANIQQEFGIPYNPQSQGVVESMNKELKKIIGQIREQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIATDMQTKELQKQITKIQNFRVYYRDSRDPIWKGPAKLLWKGEGAIVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias14-39Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK867569
EMBL· GenBank· DDBJ
QGV14950.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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